Untangling the Web of Systemic Autoinflammatory Diseases
The innate immune system is involved in the pathophysiology of systemic autoinflammatory diseases (SAIDs), an enlarging group of disorders caused by dysregulated production of proinflammatory cytokines, such as interleukin-1β and tumor necrosis factor-α, in which autoreactive T-lymphocytes and autoa...
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| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/948154 |
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| _version_ | 1832548728109531136 |
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| author | Donato Rigante Giuseppe Lopalco Antonio Vitale Orso Maria Lucherini Francesco Caso Caterina De Clemente Francesco Molinaro Mario Messina Luisa Costa Mariangela Atteno Franco Laghi-Pasini Giovanni Lapadula Mauro Galeazzi Florenzo Iannone Luca Cantarini |
| author_facet | Donato Rigante Giuseppe Lopalco Antonio Vitale Orso Maria Lucherini Francesco Caso Caterina De Clemente Francesco Molinaro Mario Messina Luisa Costa Mariangela Atteno Franco Laghi-Pasini Giovanni Lapadula Mauro Galeazzi Florenzo Iannone Luca Cantarini |
| author_sort | Donato Rigante |
| collection | DOAJ |
| description | The innate immune system is involved in the pathophysiology of systemic autoinflammatory diseases (SAIDs), an enlarging group of disorders caused by dysregulated production of proinflammatory cytokines, such as interleukin-1β and tumor necrosis factor-α, in which autoreactive T-lymphocytes and autoantibodies are indeed absent. A widely deranged innate immunity leads to overactivity of proinflammatory cytokines and subsequent multisite inflammatory symptoms depicting various conditions, such as hereditary periodic fevers, granulomatous disorders, and pyogenic diseases, collectively described in this review. Further research should enhance our understanding of the genetics behind SAIDs, unearth triggers of inflammatory attacks, and result in improvement for their diagnosis and treatment. |
| format | Article |
| id | doaj-art-2c885bb626c646e38852cbafc3b4ff93 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-2c885bb626c646e38852cbafc3b4ff932025-02-03T06:13:15ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/948154948154Untangling the Web of Systemic Autoinflammatory DiseasesDonato Rigante0Giuseppe Lopalco1Antonio Vitale2Orso Maria Lucherini3Francesco Caso4Caterina De Clemente5Francesco Molinaro6Mario Messina7Luisa Costa8Mariangela Atteno9Franco Laghi-Pasini10Giovanni Lapadula11Mauro Galeazzi12Florenzo Iannone13Luca Cantarini14Institute of Pediatrics, Policlinico A. Gemelli, Università Cattolica Sacro Cuore, Rome, ItalyInterdisciplinary Department of Medicine, Rheumatology Unit, University of Bari, Bari, ItalyResearch Center of Systemic Autoimmune and Autoinflammatory Diseases, Rheumatology Unit, Policlinico Le Scotte, University of Siena, Viale Bracci 1, 53100 Siena, ItalyResearch Center of Systemic Autoimmune and Autoinflammatory Diseases, Rheumatology Unit, Policlinico Le Scotte, University of Siena, Viale Bracci 1, 53100 Siena, ItalyResearch Center of Systemic Autoimmune and Autoinflammatory Diseases, Rheumatology Unit, Policlinico Le Scotte, University of Siena, Viale Bracci 1, 53100 Siena, ItalyResearch Center of Systemic Autoimmune and Autoinflammatory Diseases, Rheumatology Unit, Policlinico Le Scotte, University of Siena, Viale Bracci 1, 53100 Siena, ItalyDivision of Pediatric Surgery, Department of Medical Sciences, Surgery, and Neuroscience, University of Siena, Siena, ItalyDivision of Pediatric Surgery, Department of Medical Sciences, Surgery, and Neuroscience, University of Siena, Siena, ItalyRheumatology Unit, Department of Clinical Medicine and Surgery, University Federico II, Naples, ItalyRheumatology Unit, Department of Clinical Medicine and Surgery, University Federico II, Naples, ItalyDepartment of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, ItalyInterdisciplinary Department of Medicine, Rheumatology Unit, University of Bari, Bari, ItalyResearch Center of Systemic Autoimmune and Autoinflammatory Diseases, Rheumatology Unit, Policlinico Le Scotte, University of Siena, Viale Bracci 1, 53100 Siena, ItalyInterdisciplinary Department of Medicine, Rheumatology Unit, University of Bari, Bari, ItalyResearch Center of Systemic Autoimmune and Autoinflammatory Diseases, Rheumatology Unit, Policlinico Le Scotte, University of Siena, Viale Bracci 1, 53100 Siena, ItalyThe innate immune system is involved in the pathophysiology of systemic autoinflammatory diseases (SAIDs), an enlarging group of disorders caused by dysregulated production of proinflammatory cytokines, such as interleukin-1β and tumor necrosis factor-α, in which autoreactive T-lymphocytes and autoantibodies are indeed absent. A widely deranged innate immunity leads to overactivity of proinflammatory cytokines and subsequent multisite inflammatory symptoms depicting various conditions, such as hereditary periodic fevers, granulomatous disorders, and pyogenic diseases, collectively described in this review. Further research should enhance our understanding of the genetics behind SAIDs, unearth triggers of inflammatory attacks, and result in improvement for their diagnosis and treatment.http://dx.doi.org/10.1155/2014/948154 |
| spellingShingle | Donato Rigante Giuseppe Lopalco Antonio Vitale Orso Maria Lucherini Francesco Caso Caterina De Clemente Francesco Molinaro Mario Messina Luisa Costa Mariangela Atteno Franco Laghi-Pasini Giovanni Lapadula Mauro Galeazzi Florenzo Iannone Luca Cantarini Untangling the Web of Systemic Autoinflammatory Diseases Mediators of Inflammation |
| title | Untangling the Web of Systemic Autoinflammatory Diseases |
| title_full | Untangling the Web of Systemic Autoinflammatory Diseases |
| title_fullStr | Untangling the Web of Systemic Autoinflammatory Diseases |
| title_full_unstemmed | Untangling the Web of Systemic Autoinflammatory Diseases |
| title_short | Untangling the Web of Systemic Autoinflammatory Diseases |
| title_sort | untangling the web of systemic autoinflammatory diseases |
| url | http://dx.doi.org/10.1155/2014/948154 |
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