Long-Term Changes in Sarcopenia and Body Composition in Diabetes Patients with and without Charcot Osteoarthropathy
Background. Charcot osteoarthropathy of the foot (COA) can currently only be treated using prolonged periods of immobilization of the affected extremity. Therefore, the hypothesis is that COA leads to altered body composition and increased sarcopenia. Objective. To investigate the changes over sever...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2022/3142307 |
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| author | Michael Zaucha Sørensen Rasmus Bo Jansen Tomas Møller Christensen Per E. Holstein Ole Lander Svendsen |
| author_facet | Michael Zaucha Sørensen Rasmus Bo Jansen Tomas Møller Christensen Per E. Holstein Ole Lander Svendsen |
| author_sort | Michael Zaucha Sørensen |
| collection | DOAJ |
| description | Background. Charcot osteoarthropathy of the foot (COA) can currently only be treated using prolonged periods of immobilization of the affected extremity. Therefore, the hypothesis is that COA leads to altered body composition and increased sarcopenia. Objective. To investigate the changes over several years in sarcopenia, body composition, and fat distribution in diabetes patients with previous COA compared to diabetes patients without previous COA. Methods. Prospective observational clinical study. Twenty-one subjects were included and had two DXA scans done with mean 8.6-year intervals to compare changes in lean mass and fat distribution. The lean mass of limbs was used as an estimate of appendicular lean mass (aLM). Fat mass and aLM were then used to detect sarcopenic individuals using different methods. Results and Conclusions. As compared to baseline, both groups had significant loss of lean mass, and diabetics without COA had significant gain of total fat percentage. No statistically different prevalence of sarcopenia between the groups could be established. Likewise, no difference was found in total lean and fat mass changes. None of the groups had statistically significant changes of android fat distribution. As compared with published data on sarcopenia, people with diabetes might be more prone to sarcopenia than healthy individuals. |
| format | Article |
| id | doaj-art-2c6e5aa96565421898873a0ec2977d90 |
| institution | Kabale University |
| issn | 2314-6753 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-2c6e5aa96565421898873a0ec2977d902025-02-03T06:13:29ZengWileyJournal of Diabetes Research2314-67532022-01-01202210.1155/2022/3142307Long-Term Changes in Sarcopenia and Body Composition in Diabetes Patients with and without Charcot OsteoarthropathyMichael Zaucha Sørensen0Rasmus Bo Jansen1Tomas Møller Christensen2Per E. Holstein3Ole Lander Svendsen4Department of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyCopenhagen Center for Wound HealingDepartment of EndocrinologyBackground. Charcot osteoarthropathy of the foot (COA) can currently only be treated using prolonged periods of immobilization of the affected extremity. Therefore, the hypothesis is that COA leads to altered body composition and increased sarcopenia. Objective. To investigate the changes over several years in sarcopenia, body composition, and fat distribution in diabetes patients with previous COA compared to diabetes patients without previous COA. Methods. Prospective observational clinical study. Twenty-one subjects were included and had two DXA scans done with mean 8.6-year intervals to compare changes in lean mass and fat distribution. The lean mass of limbs was used as an estimate of appendicular lean mass (aLM). Fat mass and aLM were then used to detect sarcopenic individuals using different methods. Results and Conclusions. As compared to baseline, both groups had significant loss of lean mass, and diabetics without COA had significant gain of total fat percentage. No statistically different prevalence of sarcopenia between the groups could be established. Likewise, no difference was found in total lean and fat mass changes. None of the groups had statistically significant changes of android fat distribution. As compared with published data on sarcopenia, people with diabetes might be more prone to sarcopenia than healthy individuals.http://dx.doi.org/10.1155/2022/3142307 |
| spellingShingle | Michael Zaucha Sørensen Rasmus Bo Jansen Tomas Møller Christensen Per E. Holstein Ole Lander Svendsen Long-Term Changes in Sarcopenia and Body Composition in Diabetes Patients with and without Charcot Osteoarthropathy Journal of Diabetes Research |
| title | Long-Term Changes in Sarcopenia and Body Composition in Diabetes Patients with and without Charcot Osteoarthropathy |
| title_full | Long-Term Changes in Sarcopenia and Body Composition in Diabetes Patients with and without Charcot Osteoarthropathy |
| title_fullStr | Long-Term Changes in Sarcopenia and Body Composition in Diabetes Patients with and without Charcot Osteoarthropathy |
| title_full_unstemmed | Long-Term Changes in Sarcopenia and Body Composition in Diabetes Patients with and without Charcot Osteoarthropathy |
| title_short | Long-Term Changes in Sarcopenia and Body Composition in Diabetes Patients with and without Charcot Osteoarthropathy |
| title_sort | long term changes in sarcopenia and body composition in diabetes patients with and without charcot osteoarthropathy |
| url | http://dx.doi.org/10.1155/2022/3142307 |
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