A pilot study : retinal sensitivity change in neovascular age-related macular degeneration patients with better baseline visual acuity
Abstract This study evaluated changes in retinal sensitivity (RS) during aflibercept treatment in neovascular age-related macular degeneration (nAMD) patients with good vision. Treatment-naive nAMD patients with visual acuity better than 20/40 were treated with an aflibercept loading regiment, and R...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-11-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-77485-5 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850196025256443904 |
|---|---|
| author | Jae Hyup Lee Hyeong Gon Yu Chang Ki Yoon |
| author_facet | Jae Hyup Lee Hyeong Gon Yu Chang Ki Yoon |
| author_sort | Jae Hyup Lee |
| collection | DOAJ |
| description | Abstract This study evaluated changes in retinal sensitivity (RS) during aflibercept treatment in neovascular age-related macular degeneration (nAMD) patients with good vision. Treatment-naive nAMD patients with visual acuity better than 20/40 were treated with an aflibercept loading regiment, and RS was measured using the MAIA microperimetry device. The study examined RS differences based on visit, region, adjacent local pathology, outer retinal changes and optical coherence tomography angiography (OCTA) data were investigated. Twelve patients completed the protocol. Mean RS improved from 17.9 (3.9) µm at baseline to 20.4 (4.7) µm at final visit, while best-corrected visual acuity (BCVA) did not change. (P = 0.041) RS at baseline is worst in the presence of intraretinal fluid (IRF) and improved after treatment for all retinal pathologies except IRF. RS improvement occurred even with initial outer retinal damage. A Linear mixed model showed subretinal hyperreflective material, baseline IRF height, outer retinal integrity, fibrovascular pigment epithelial detachment height, and local choroidal vascular index as factors associated with RS. In conclusion, RS improved with aflibercept treatment in nAMD eyes with good initial visual acuity, despite no change in BCVA, except when IRF was present. |
| format | Article |
| id | doaj-art-2c68dbeff4bb4e32ae4dfd33ed2bf2a0 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-2c68dbeff4bb4e32ae4dfd33ed2bf2a02025-08-20T02:13:35ZengNature PortfolioScientific Reports2045-23222024-11-0114111210.1038/s41598-024-77485-5A pilot study : retinal sensitivity change in neovascular age-related macular degeneration patients with better baseline visual acuityJae Hyup Lee0Hyeong Gon Yu1Chang Ki Yoon2Department of Ophthalmology, Inje University College of Medicine, Busan Paik HospitalSky Eye ClinicDepartment of Ophthalmology, Seoul National University College of Medicine, Seoul National University HospitalAbstract This study evaluated changes in retinal sensitivity (RS) during aflibercept treatment in neovascular age-related macular degeneration (nAMD) patients with good vision. Treatment-naive nAMD patients with visual acuity better than 20/40 were treated with an aflibercept loading regiment, and RS was measured using the MAIA microperimetry device. The study examined RS differences based on visit, region, adjacent local pathology, outer retinal changes and optical coherence tomography angiography (OCTA) data were investigated. Twelve patients completed the protocol. Mean RS improved from 17.9 (3.9) µm at baseline to 20.4 (4.7) µm at final visit, while best-corrected visual acuity (BCVA) did not change. (P = 0.041) RS at baseline is worst in the presence of intraretinal fluid (IRF) and improved after treatment for all retinal pathologies except IRF. RS improvement occurred even with initial outer retinal damage. A Linear mixed model showed subretinal hyperreflective material, baseline IRF height, outer retinal integrity, fibrovascular pigment epithelial detachment height, and local choroidal vascular index as factors associated with RS. In conclusion, RS improved with aflibercept treatment in nAMD eyes with good initial visual acuity, despite no change in BCVA, except when IRF was present.https://doi.org/10.1038/s41598-024-77485-5AfliberceptMicroperimetryNeovascular age-related macular degenerationRetinal sensitivity |
| spellingShingle | Jae Hyup Lee Hyeong Gon Yu Chang Ki Yoon A pilot study : retinal sensitivity change in neovascular age-related macular degeneration patients with better baseline visual acuity Scientific Reports Aflibercept Microperimetry Neovascular age-related macular degeneration Retinal sensitivity |
| title | A pilot study : retinal sensitivity change in neovascular age-related macular degeneration patients with better baseline visual acuity |
| title_full | A pilot study : retinal sensitivity change in neovascular age-related macular degeneration patients with better baseline visual acuity |
| title_fullStr | A pilot study : retinal sensitivity change in neovascular age-related macular degeneration patients with better baseline visual acuity |
| title_full_unstemmed | A pilot study : retinal sensitivity change in neovascular age-related macular degeneration patients with better baseline visual acuity |
| title_short | A pilot study : retinal sensitivity change in neovascular age-related macular degeneration patients with better baseline visual acuity |
| title_sort | pilot study retinal sensitivity change in neovascular age related macular degeneration patients with better baseline visual acuity |
| topic | Aflibercept Microperimetry Neovascular age-related macular degeneration Retinal sensitivity |
| url | https://doi.org/10.1038/s41598-024-77485-5 |
| work_keys_str_mv | AT jaehyuplee apilotstudyretinalsensitivitychangeinneovascularagerelatedmaculardegenerationpatientswithbetterbaselinevisualacuity AT hyeonggonyu apilotstudyretinalsensitivitychangeinneovascularagerelatedmaculardegenerationpatientswithbetterbaselinevisualacuity AT changkiyoon apilotstudyretinalsensitivitychangeinneovascularagerelatedmaculardegenerationpatientswithbetterbaselinevisualacuity AT jaehyuplee pilotstudyretinalsensitivitychangeinneovascularagerelatedmaculardegenerationpatientswithbetterbaselinevisualacuity AT hyeonggonyu pilotstudyretinalsensitivitychangeinneovascularagerelatedmaculardegenerationpatientswithbetterbaselinevisualacuity AT changkiyoon pilotstudyretinalsensitivitychangeinneovascularagerelatedmaculardegenerationpatientswithbetterbaselinevisualacuity |