PPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain Invasion
Today, there is increasing evidence that PPARγ agonists, including thiazolidinediones (TDZs) and nonthiazolidinediones, block the motility and invasiveness of glioma cells and other highly migratory tumor entities. However, the mechanism(s) by which PPARγ activators mediate their antimigratory and a...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2008/513943 |
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| _version_ | 1832561207671783424 |
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| author | Sebastian Seufert Roland Coras Christian Tränkle Darius P. Zlotos Ingmar Blümcke Lars Tatenhorst Michael T. Heneka Eric Hahnen |
| author_facet | Sebastian Seufert Roland Coras Christian Tränkle Darius P. Zlotos Ingmar Blümcke Lars Tatenhorst Michael T. Heneka Eric Hahnen |
| author_sort | Sebastian Seufert |
| collection | DOAJ |
| description | Today, there is increasing evidence that PPARγ agonists, including thiazolidinediones (TDZs) and nonthiazolidinediones, block the motility and invasiveness of glioma cells and other highly migratory tumor entities. However, the mechanism(s) by which PPARγ activators mediate their antimigratory and anti-invasive properties remains elusive. This letter gives a short review on the debate and adds to the current knowledge by applying a PPARγ inactive derivative of the TDZ troglitazone (Rezulin) which potently counteracts experimental glioma progression in a PPARγ independent manner. |
| format | Article |
| id | doaj-art-2c61bcf6f78a4fd497f37037228a77f4 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-2c61bcf6f78a4fd497f37037228a77f42025-02-03T01:25:38ZengWileyPPAR Research1687-47571687-47652008-01-01200810.1155/2008/513943513943PPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain InvasionSebastian Seufert0Roland Coras1Christian Tränkle2Darius P. Zlotos3Ingmar Blümcke4Lars Tatenhorst5Michael T. Heneka6Eric Hahnen7Institute of Human Genetics, Institute of Genetics, and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Kerpener Street 34, 50931 Cologne, GermanyInstitute of Neuropathology, University of Erlangen, GermanyDepartment of Pharmacology and Toxicology, Institute of Pharmacy, University of Bonn, 53121 Bonn, GermanyPharmaceutical Institute, University of Würzburg, 97074 Würzburg, GermanyInstitute of Neuropathology, University of Erlangen, GermanyDepartment of Neurology, University of Bonn, 53105 Bonn, GermanyDepartment of Neurology, University of Bonn, 53105 Bonn, GermanyInstitute of Human Genetics, Institute of Genetics, and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Kerpener Street 34, 50931 Cologne, GermanyToday, there is increasing evidence that PPARγ agonists, including thiazolidinediones (TDZs) and nonthiazolidinediones, block the motility and invasiveness of glioma cells and other highly migratory tumor entities. However, the mechanism(s) by which PPARγ activators mediate their antimigratory and anti-invasive properties remains elusive. This letter gives a short review on the debate and adds to the current knowledge by applying a PPARγ inactive derivative of the TDZ troglitazone (Rezulin) which potently counteracts experimental glioma progression in a PPARγ independent manner.http://dx.doi.org/10.1155/2008/513943 |
| spellingShingle | Sebastian Seufert Roland Coras Christian Tränkle Darius P. Zlotos Ingmar Blümcke Lars Tatenhorst Michael T. Heneka Eric Hahnen PPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain Invasion PPAR Research |
| title | PPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain Invasion |
| title_full | PPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain Invasion |
| title_fullStr | PPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain Invasion |
| title_full_unstemmed | PPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain Invasion |
| title_short | PPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain Invasion |
| title_sort | ppar gamma activators off target against glioma cell migration and brain invasion |
| url | http://dx.doi.org/10.1155/2008/513943 |
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