Inflammasomes in neurodegenerative diseases
Abstract Inflammasomes represent a crucial component of the innate immune system, which respond to threats by recognizing different molecules. These are known as pathogen-associated molecular patterns (PAMPs) or host-derived damage-associated molecular patterns (DAMPs). In neurodegenerative diseases...
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| Format: | Article |
| Language: | English |
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BMC
2024-12-01
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| Series: | Translational Neurodegeneration |
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| Online Access: | https://doi.org/10.1186/s40035-024-00459-0 |
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| _version_ | 1832585411101196288 |
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| author | Qianchen Wang Songwei Yang Xuan Zhang Shanshan Zhang Liping Chen Wanxue Wang Naihong Chen Jiaqing Yan |
| author_facet | Qianchen Wang Songwei Yang Xuan Zhang Shanshan Zhang Liping Chen Wanxue Wang Naihong Chen Jiaqing Yan |
| author_sort | Qianchen Wang |
| collection | DOAJ |
| description | Abstract Inflammasomes represent a crucial component of the innate immune system, which respond to threats by recognizing different molecules. These are known as pathogen-associated molecular patterns (PAMPs) or host-derived damage-associated molecular patterns (DAMPs). In neurodegenerative diseases and neuroinflammation, the accumulation of misfolded proteins, such as beta-amyloid and alpha-synuclein, can lead to inflammasome activation, resulting in the release of interleukin (IL)-1β and IL-18. This activation also induces pyroptosis, the release of inflammatory mediators, and exacerbates neuroinflammation. Increasing evidence suggests that inflammasomes play a pivotal role in neurodegenerative diseases. Therefore, elucidating and investigating the activation and regulation of inflammasomes in these diseases is of paramount importance. This review is primarily focused on evidence indicating that inflammasomes are activated through the canonical pathway in these diseases. Inflammasomes as potential targets for treating neurodegenerative diseases are also discussed. |
| format | Article |
| id | doaj-art-2c567a9bf9b642d3a8bc6abc780aa189 |
| institution | Kabale University |
| issn | 2047-9158 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Translational Neurodegeneration |
| spelling | doaj-art-2c567a9bf9b642d3a8bc6abc780aa1892025-01-26T12:49:55ZengBMCTranslational Neurodegeneration2047-91582024-12-0113112210.1186/s40035-024-00459-0Inflammasomes in neurodegenerative diseasesQianchen Wang0Songwei Yang1Xuan Zhang2Shanshan Zhang3Liping Chen4Wanxue Wang5Naihong Chen6Jiaqing Yan7Department of Pharmacy, The First Affiliated Hospital of China Medical UniversityHunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, School of Pharmacy, Hunan University of Chinese MedicineDepartment of Pharmacy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeChina Three Gorges University College of Medicine and Health SciencesDepartment of Pharmacy, The First Affiliated Hospital of China Medical UniversityState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica and Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical CollegeState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica and Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Pharmacy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeAbstract Inflammasomes represent a crucial component of the innate immune system, which respond to threats by recognizing different molecules. These are known as pathogen-associated molecular patterns (PAMPs) or host-derived damage-associated molecular patterns (DAMPs). In neurodegenerative diseases and neuroinflammation, the accumulation of misfolded proteins, such as beta-amyloid and alpha-synuclein, can lead to inflammasome activation, resulting in the release of interleukin (IL)-1β and IL-18. This activation also induces pyroptosis, the release of inflammatory mediators, and exacerbates neuroinflammation. Increasing evidence suggests that inflammasomes play a pivotal role in neurodegenerative diseases. Therefore, elucidating and investigating the activation and regulation of inflammasomes in these diseases is of paramount importance. This review is primarily focused on evidence indicating that inflammasomes are activated through the canonical pathway in these diseases. Inflammasomes as potential targets for treating neurodegenerative diseases are also discussed.https://doi.org/10.1186/s40035-024-00459-0InflammasomeNeurodegenerative diseasesNeurodegenerationNeuroinflammationMicroglia |
| spellingShingle | Qianchen Wang Songwei Yang Xuan Zhang Shanshan Zhang Liping Chen Wanxue Wang Naihong Chen Jiaqing Yan Inflammasomes in neurodegenerative diseases Translational Neurodegeneration Inflammasome Neurodegenerative diseases Neurodegeneration Neuroinflammation Microglia |
| title | Inflammasomes in neurodegenerative diseases |
| title_full | Inflammasomes in neurodegenerative diseases |
| title_fullStr | Inflammasomes in neurodegenerative diseases |
| title_full_unstemmed | Inflammasomes in neurodegenerative diseases |
| title_short | Inflammasomes in neurodegenerative diseases |
| title_sort | inflammasomes in neurodegenerative diseases |
| topic | Inflammasome Neurodegenerative diseases Neurodegeneration Neuroinflammation Microglia |
| url | https://doi.org/10.1186/s40035-024-00459-0 |
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