Global, regional, and national epidemiology of childhood neuroblastoma (1990–2021): a statistical analysis of incidence, mortality, and DALYsResearch in context
Summary: Background: Neuroblastoma is the most prevalent extracranial solid tumor in pediatric populations worldwide, representing 8–10% of childhood malignancies and contributing to approximately 15% of pediatric cancer-related fatalities. This study aims to report global trends in the incidence,...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | EClinicalMedicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589537024005431 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832591755945443328 |
|---|---|
| author | Jusen Nong Cheng Su Changhua Li Congjun Wang Wei Li Yong Li Peng Chen Yanqiang Li Zihao Li Xinjin She Zuxin Yuan Sentian Liu Chao Chen Qian Liao Yige Luo Bo Shi |
| author_facet | Jusen Nong Cheng Su Changhua Li Congjun Wang Wei Li Yong Li Peng Chen Yanqiang Li Zihao Li Xinjin She Zuxin Yuan Sentian Liu Chao Chen Qian Liao Yige Luo Bo Shi |
| author_sort | Jusen Nong |
| collection | DOAJ |
| description | Summary: Background: Neuroblastoma is the most prevalent extracranial solid tumor in pediatric populations worldwide, representing 8–10% of childhood malignancies and contributing to approximately 15% of pediatric cancer-related fatalities. This study aims to report global trends in the incidence, mortality, and disability-adjusted life years (DALYs) of childhood neuroblastoma from 1990 to 2021. Methods: The study utilized data from the Global Burden of Disease (GBD) database to analyze neuroblastoma incidence, mortality, and DALYs in children aged 0–14 years. Rates for incidence, mortality, and DALYs were calculated per 100,000 population, with 95% uncertainty intervals (UIs). Data from 204 countries and territories were stratified by age, sex, and location. Trends were assessed using Joinpoint regression models to compute the annual percent change (APC) and log-transformed linear regression models to calculate the estimated average annual percentage change (EAPC). Findings: Globally, the incidence of neuroblastoma in children in 2021 was 5560 cases (95% UI, 3734.21–7560.03), with 1977 deaths (95% UI, 1445.04–2528.54), and 174,186.30 DALYs (95% UI, 127,104.64–223,265.92). From 1990 to 2021, the incidence increased by 30.26% (95% UI, −1.24% to 72.51%), mortality by 20.35% (95% UI, −12.44% to 63.30%), and DALYs by 20.08% (95% UI, −12.89% to 63.27%). The incidence rate rose from 0.25 (95% UI, 0.18–0.33) per 100,000 individuals in 1990 to 0.28 (95% UI, 0.19–0.38) per 100,000 individuals in 2021, an overall increase of 12.60% (95% UI, −14.62% to 49.12%). Among the five Sociodemographic Index (SDI) regions, the highest EAPCs were observed in the low-to-mid SDI regions for incidence (1.87%; 95% CI, 1.64%–2.10%), mortality (1.22%; 95% CI, 1.09%–1.34%), and DALYs (1.36%; 95% CI, 1.15%–1.57%). Regionally, Central Asia exhibited the fastest annual increase in incidence (EAPC = 2.76%; 95% CI, 2.18%–3.34%). At the national level, India had the highest number of neuroblastoma cases globally in 2021, with 685 cases (95% UI, 404.16–1007.67). Interpretation: The global trends for incidence, mortality, and DALYs related to pediatric neuroblastoma initially increased and then decreased, although an overall increasing trend was observed. However, the burden of disease remains significant in low-, low-middle-, and middle-SDI regions. A comprehensive understanding of the epidemiology of neuroblastoma in children is crucial for enhancing disease prevention and control efforts. Funding: This research was funded by the Guangxi Natural Science Foundation (Grant No. 2024GXNSFAA010420) and the Youth Science Foundation of Guangxi Medical University (Grant No. GXMUYSF202404). |
| format | Article |
| id | doaj-art-2c4896405376427ca18c74fdf99966d9 |
| institution | Kabale University |
| issn | 2589-5370 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EClinicalMedicine |
| spelling | doaj-art-2c4896405376427ca18c74fdf99966d92025-01-22T05:43:10ZengElsevierEClinicalMedicine2589-53702025-01-0179102964Global, regional, and national epidemiology of childhood neuroblastoma (1990–2021): a statistical analysis of incidence, mortality, and DALYsResearch in contextJusen Nong0Cheng Su1Changhua Li2Congjun Wang3Wei Li4Yong Li5Peng Chen6Yanqiang Li7Zihao Li8Xinjin She9Zuxin Yuan10Sentian Liu11Chao Chen12Qian Liao13Yige Luo14Bo Shi15Department of Pediatric Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, PR ChinaDepartment of Pediatric Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, PR ChinaDepartment of Emergency, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, PR ChinaDepartment of Pediatric Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, PR ChinaDepartment of Pediatric Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, PR ChinaDepartment of Pediatric Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, PR ChinaDepartment of Pediatric Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, PR ChinaDepartment of Pediatric Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, PR ChinaDepartment of Thoracic Surgery, Liuzhou People's Hospital Affiliated to Guangxi Medical University, Liuzhou, Guangxi Zhuang Autonomous Region, PR ChinaDepartment of Pediatric Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, PR ChinaDepartment of Pediatric Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, PR ChinaDepartment of Pediatric Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, PR ChinaDepartment of Pediatric Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, PR ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, PR ChinaDepartment of Pediatric Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, PR China; Corresponding author. Department of Pediatric Surgery, The First Affiliated Hospital of Guangxi Medical University, Shuang Yong Rd. 6#, Nanning, 530021, Guangxi Zhuang Autonomous Region, PR China.Department of Pediatric Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, PR China; Corresponding author. Department of Pediatric Surgery, The First Affiliated Hospital of Guangxi Medical University, Shuang Yong Rd. 6#, Nanning, 530021, Guangxi Zhuang Autonomous Region, PR China.Summary: Background: Neuroblastoma is the most prevalent extracranial solid tumor in pediatric populations worldwide, representing 8–10% of childhood malignancies and contributing to approximately 15% of pediatric cancer-related fatalities. This study aims to report global trends in the incidence, mortality, and disability-adjusted life years (DALYs) of childhood neuroblastoma from 1990 to 2021. Methods: The study utilized data from the Global Burden of Disease (GBD) database to analyze neuroblastoma incidence, mortality, and DALYs in children aged 0–14 years. Rates for incidence, mortality, and DALYs were calculated per 100,000 population, with 95% uncertainty intervals (UIs). Data from 204 countries and territories were stratified by age, sex, and location. Trends were assessed using Joinpoint regression models to compute the annual percent change (APC) and log-transformed linear regression models to calculate the estimated average annual percentage change (EAPC). Findings: Globally, the incidence of neuroblastoma in children in 2021 was 5560 cases (95% UI, 3734.21–7560.03), with 1977 deaths (95% UI, 1445.04–2528.54), and 174,186.30 DALYs (95% UI, 127,104.64–223,265.92). From 1990 to 2021, the incidence increased by 30.26% (95% UI, −1.24% to 72.51%), mortality by 20.35% (95% UI, −12.44% to 63.30%), and DALYs by 20.08% (95% UI, −12.89% to 63.27%). The incidence rate rose from 0.25 (95% UI, 0.18–0.33) per 100,000 individuals in 1990 to 0.28 (95% UI, 0.19–0.38) per 100,000 individuals in 2021, an overall increase of 12.60% (95% UI, −14.62% to 49.12%). Among the five Sociodemographic Index (SDI) regions, the highest EAPCs were observed in the low-to-mid SDI regions for incidence (1.87%; 95% CI, 1.64%–2.10%), mortality (1.22%; 95% CI, 1.09%–1.34%), and DALYs (1.36%; 95% CI, 1.15%–1.57%). Regionally, Central Asia exhibited the fastest annual increase in incidence (EAPC = 2.76%; 95% CI, 2.18%–3.34%). At the national level, India had the highest number of neuroblastoma cases globally in 2021, with 685 cases (95% UI, 404.16–1007.67). Interpretation: The global trends for incidence, mortality, and DALYs related to pediatric neuroblastoma initially increased and then decreased, although an overall increasing trend was observed. However, the burden of disease remains significant in low-, low-middle-, and middle-SDI regions. A comprehensive understanding of the epidemiology of neuroblastoma in children is crucial for enhancing disease prevention and control efforts. Funding: This research was funded by the Guangxi Natural Science Foundation (Grant No. 2024GXNSFAA010420) and the Youth Science Foundation of Guangxi Medical University (Grant No. GXMUYSF202404).http://www.sciencedirect.com/science/article/pii/S2589537024005431NeuroblastomaGlobal burden of disease studyIncidenceMortalityChildhood |
| spellingShingle | Jusen Nong Cheng Su Changhua Li Congjun Wang Wei Li Yong Li Peng Chen Yanqiang Li Zihao Li Xinjin She Zuxin Yuan Sentian Liu Chao Chen Qian Liao Yige Luo Bo Shi Global, regional, and national epidemiology of childhood neuroblastoma (1990–2021): a statistical analysis of incidence, mortality, and DALYsResearch in context EClinicalMedicine Neuroblastoma Global burden of disease study Incidence Mortality Childhood |
| title | Global, regional, and national epidemiology of childhood neuroblastoma (1990–2021): a statistical analysis of incidence, mortality, and DALYsResearch in context |
| title_full | Global, regional, and national epidemiology of childhood neuroblastoma (1990–2021): a statistical analysis of incidence, mortality, and DALYsResearch in context |
| title_fullStr | Global, regional, and national epidemiology of childhood neuroblastoma (1990–2021): a statistical analysis of incidence, mortality, and DALYsResearch in context |
| title_full_unstemmed | Global, regional, and national epidemiology of childhood neuroblastoma (1990–2021): a statistical analysis of incidence, mortality, and DALYsResearch in context |
| title_short | Global, regional, and national epidemiology of childhood neuroblastoma (1990–2021): a statistical analysis of incidence, mortality, and DALYsResearch in context |
| title_sort | global regional and national epidemiology of childhood neuroblastoma 1990 2021 a statistical analysis of incidence mortality and dalysresearch in context |
| topic | Neuroblastoma Global burden of disease study Incidence Mortality Childhood |
| url | http://www.sciencedirect.com/science/article/pii/S2589537024005431 |
| work_keys_str_mv | AT jusennong globalregionalandnationalepidemiologyofchildhoodneuroblastoma19902021astatisticalanalysisofincidencemortalityanddalysresearchincontext AT chengsu globalregionalandnationalepidemiologyofchildhoodneuroblastoma19902021astatisticalanalysisofincidencemortalityanddalysresearchincontext AT changhuali globalregionalandnationalepidemiologyofchildhoodneuroblastoma19902021astatisticalanalysisofincidencemortalityanddalysresearchincontext AT congjunwang globalregionalandnationalepidemiologyofchildhoodneuroblastoma19902021astatisticalanalysisofincidencemortalityanddalysresearchincontext AT weili globalregionalandnationalepidemiologyofchildhoodneuroblastoma19902021astatisticalanalysisofincidencemortalityanddalysresearchincontext AT yongli globalregionalandnationalepidemiologyofchildhoodneuroblastoma19902021astatisticalanalysisofincidencemortalityanddalysresearchincontext AT pengchen globalregionalandnationalepidemiologyofchildhoodneuroblastoma19902021astatisticalanalysisofincidencemortalityanddalysresearchincontext AT yanqiangli globalregionalandnationalepidemiologyofchildhoodneuroblastoma19902021astatisticalanalysisofincidencemortalityanddalysresearchincontext AT zihaoli globalregionalandnationalepidemiologyofchildhoodneuroblastoma19902021astatisticalanalysisofincidencemortalityanddalysresearchincontext AT xinjinshe globalregionalandnationalepidemiologyofchildhoodneuroblastoma19902021astatisticalanalysisofincidencemortalityanddalysresearchincontext AT zuxinyuan globalregionalandnationalepidemiologyofchildhoodneuroblastoma19902021astatisticalanalysisofincidencemortalityanddalysresearchincontext AT sentianliu globalregionalandnationalepidemiologyofchildhoodneuroblastoma19902021astatisticalanalysisofincidencemortalityanddalysresearchincontext AT chaochen globalregionalandnationalepidemiologyofchildhoodneuroblastoma19902021astatisticalanalysisofincidencemortalityanddalysresearchincontext AT qianliao globalregionalandnationalepidemiologyofchildhoodneuroblastoma19902021astatisticalanalysisofincidencemortalityanddalysresearchincontext AT yigeluo globalregionalandnationalepidemiologyofchildhoodneuroblastoma19902021astatisticalanalysisofincidencemortalityanddalysresearchincontext AT boshi globalregionalandnationalepidemiologyofchildhoodneuroblastoma19902021astatisticalanalysisofincidencemortalityanddalysresearchincontext |