Analysis of transcriptome and chromatin accessibility changes during the differentiation of human embryonic stem cells into neural progenitor cells

Analysis of transcriptome and chromatin accessibility changes during the differentiation of human embryonic stem cells into neural progenitor cells

Objective·To investigate the changes in transcriptome and chromatin accessibility during the differentiation of human embryonic stem cells (hESCs) into neural progenitor cells (NPCs) using in vitro differentiation models and high-throughput multi-omics sequencing technologies.Methods·hESCs were firs...

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Bibliographic Details
Main Authors: LI Linying, CAI Xiaodong, TONG Ran, YANG Chen, WANG Zhiming, HE Xiaoyu, MA Ziyue, ZHANG Feng, LI Lingjie, ZHOU Junmei
Format: Article
Language:zho
Published: Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science) 2025-04-01
Series:Shanghai Jiaotong Daxue xuebao. Yixue ban
Subjects:
human embryonic stem cell (hesc)
neural progenitor cell (npc)
assay for transposase-accessible chromatin with sequencing (atac-seq)
rna sequencing (rna-seq)
Online Access:https://xuebao.shsmu.edu.cn/article/2025/1674-8115/1674-8115-2025-45-4-387.shtml
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https://xuebao.shsmu.edu.cn/article/2025/1674-8115/1674-8115-2025-45-4-387.shtml

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