A Primer on the Role of TP53 Mutation and Targeted Therapy in Endometrial Cancer
Endometrial Cancer (EC) is one of the most common gynecological malignancies, ranking first in developed countries and regions. The occurrence and development of EC is closely associated with genetic mutations. TP53 mutation, in particular, can lead to the dysfunction of numerous regulatory factors...
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| Format: | Article |
| Language: | English |
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IMR Press
2025-01-01
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| Series: | Frontiers in Bioscience-Landmark |
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| Online Access: | https://www.imrpress.com/journal/FBL/30/1/10.31083/FBL25447 |
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| author | Bohao Zhang Haozhe Zhang Yanru Qin |
| author_facet | Bohao Zhang Haozhe Zhang Yanru Qin |
| author_sort | Bohao Zhang |
| collection | DOAJ |
| description | Endometrial Cancer (EC) is one of the most common gynecological malignancies, ranking first in developed countries and regions. The occurrence and development of EC is closely associated with genetic mutations. TP53 mutation, in particular, can lead to the dysfunction of numerous regulatory factors and alteration of the tumor microenvironment (TME). The changes in the TME subsequently promote the development of tumors and assist in immune escape by tumor cells, making it more challenging to treat EC and resulting in a poor prognosis. Therefore, it is important to understand the effects of TP53 mutation in EC and to conduct further research in relation to the targeting of TP53 mutations. This article reviews current research progress on the role of TP53 mutations in regulating the TME and in the mechanism of EC tumorigenesis, as well as progress on drugs that target TP53 mutations. |
| format | Article |
| id | doaj-art-2c4781d47b1c4a2aa403ca52a1671916 |
| institution | Kabale University |
| issn | 2768-6701 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj-art-2c4781d47b1c4a2aa403ca52a16719162025-01-25T08:55:52ZengIMR PressFrontiers in Bioscience-Landmark2768-67012025-01-013012544710.31083/FBL25447S2768-6701(24)01489-8A Primer on the Role of TP53 Mutation and Targeted Therapy in Endometrial CancerBohao Zhang0Haozhe Zhang1Yanru Qin2Department of Oncology, The First Affiliated Hospital of Zhengzhou Hospital of Zhengzhou University, 450000 Zhengzhou, Henan, ChinaDepartment of Oncology, The First Affiliated Hospital of Zhengzhou Hospital of Zhengzhou University, 450000 Zhengzhou, Henan, ChinaDepartment of Oncology, The First Affiliated Hospital of Zhengzhou Hospital of Zhengzhou University, 450000 Zhengzhou, Henan, ChinaEndometrial Cancer (EC) is one of the most common gynecological malignancies, ranking first in developed countries and regions. The occurrence and development of EC is closely associated with genetic mutations. TP53 mutation, in particular, can lead to the dysfunction of numerous regulatory factors and alteration of the tumor microenvironment (TME). The changes in the TME subsequently promote the development of tumors and assist in immune escape by tumor cells, making it more challenging to treat EC and resulting in a poor prognosis. Therefore, it is important to understand the effects of TP53 mutation in EC and to conduct further research in relation to the targeting of TP53 mutations. This article reviews current research progress on the role of TP53 mutations in regulating the TME and in the mechanism of EC tumorigenesis, as well as progress on drugs that target TP53 mutations.https://www.imrpress.com/journal/FBL/30/1/10.31083/FBL25447tp53 mutationsp53 proteintargeted therapiesendometrial cancer |
| spellingShingle | Bohao Zhang Haozhe Zhang Yanru Qin A Primer on the Role of TP53 Mutation and Targeted Therapy in Endometrial Cancer Frontiers in Bioscience-Landmark tp53 mutations p53 protein targeted therapies endometrial cancer |
| title | A Primer on the Role of TP53 Mutation and Targeted Therapy in Endometrial Cancer |
| title_full | A Primer on the Role of TP53 Mutation and Targeted Therapy in Endometrial Cancer |
| title_fullStr | A Primer on the Role of TP53 Mutation and Targeted Therapy in Endometrial Cancer |
| title_full_unstemmed | A Primer on the Role of TP53 Mutation and Targeted Therapy in Endometrial Cancer |
| title_short | A Primer on the Role of TP53 Mutation and Targeted Therapy in Endometrial Cancer |
| title_sort | primer on the role of tp53 mutation and targeted therapy in endometrial cancer |
| topic | tp53 mutations p53 protein targeted therapies endometrial cancer |
| url | https://www.imrpress.com/journal/FBL/30/1/10.31083/FBL25447 |
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