Endothelial HSPA12B regulates myocardial monocyte infiltration and inflammatory activity after myocardial infarction

Endothelial HSPA12B regulates myocardial monocyte infiltration and inflammatory activity after myocardial infarction

IntroductionCardiac macrophages are essential mediators of inflammation and tissue remodeling following myocardial infarction (MI). Endothelial cell-specific heat shock protein A12B (eHSPA12B) has emerged as a key vascular regulator, but its role in modulating immune cell responses after MI remains...

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Bibliographic Details
Main Authors: Yana Wang, Min Fan, Linjian Chen, Patrick Spencer Gill, Xiaohui Wang, Tuanzhu Ha, David L. Williams, Chuanfu Li, Kun Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
myocardial infarction
endothelial cells
HSPA12B
exosome
cardiac resident macrophages
cardiac infiltrated monocytes
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1587898/full
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