γ-Secretase modulator resistance of an aggressive Alzheimer-causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compounds

γ-Secretase modulator resistance of an aggressive Alzheimer-causing presenilin mutant can be overcome in the heterozygous patient state by a set of advanced compounds

Abstract Background Amyloid-β peptide (Aβ) species of 42 or 43 amino acids in length (Aβ42/43) trigger Alzheimer´s disease (AD) and are produced in abnormal amounts by mutants of the γ-secretase subunit presenilin-1 (PS1), which represent the primary cause of familial AD (FAD). Lowering these peptid...

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Main Authors: Johannes Trambauer, Rosa Maria Rodriguez Sarmiento, Holly J. Garringer, Katja Salbaum, Liliana D. Pedro, Dennis Crusius, Ruben Vidal, Bernardino Ghetti, Dominik Paquet, Karlheinz Baumann, Lothar Lindemann, Harald Steiner
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
γ-Secretase modulator
Aβ
Presenilin
Familial Alzheimer’s disease
Online Access:https://doi.org/10.1186/s13195-025-01680-3
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