Biomarkers of Guillain-Barré Syndrome: Some Recent Progress, More Still to Be Explored
Guillain-Barré syndrome (GBS), the axonal subtype of which is mainly triggered by C. jejuni with ganglioside-mimicking lipooligosaccharides (LOS), is an immune-mediated disorder in the peripheral nervous system (PNS) accompanied by the disruption of the blood-nerve barrier (BNB) and the blood-cerebr...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/564098 |
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| author | Ying Wang Shuang Sun Jie Zhu Li Cui Hong-Liang Zhang |
| author_facet | Ying Wang Shuang Sun Jie Zhu Li Cui Hong-Liang Zhang |
| author_sort | Ying Wang |
| collection | DOAJ |
| description | Guillain-Barré syndrome (GBS), the axonal subtype of which is mainly triggered by C. jejuni with ganglioside-mimicking lipooligosaccharides (LOS), is an immune-mediated disorder in the peripheral nervous system (PNS) accompanied by the disruption of the blood-nerve barrier (BNB) and the blood-cerebrospinal fluid barrier (B-CSF-B). Biomarkers of GBS have been extensively explored and some of them are proved to assist in the clinical diagnosis and in monitoring disease progression as well as in assessing the efficacy of immunotherapy. Herein, we systemically review the literature on biomarkers of GBS, including infection-/immune-/BNB, B-CSF-B, and PNS damage-associated biomarkers, aiming at providing an overview of GBS biomarkers and guiding further investigations. Furthermore, we point out further directions for studies on GBS biomarkers. |
| format | Article |
| id | doaj-art-2c38ab85ed1e4bf9a4e4962ccb2996fc |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-2c38ab85ed1e4bf9a4e4962ccb2996fc2025-02-03T01:02:19ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/564098564098Biomarkers of Guillain-Barré Syndrome: Some Recent Progress, More Still to Be ExploredYing Wang0Shuang Sun1Jie Zhu2Li Cui3Hong-Liang Zhang4Neuroscience Center, Department of Neurology, The First Hospital of Jilin University, Changchun 130000, ChinaDepartment of Neurology, Heilongjiang Provincial Hospital, Harbin, ChinaNeuroscience Center, Department of Neurology, The First Hospital of Jilin University, Changchun 130000, ChinaNeuroscience Center, Department of Neurology, The First Hospital of Jilin University, Changchun 130000, ChinaNeuroscience Center, Department of Neurology, The First Hospital of Jilin University, Changchun 130000, ChinaGuillain-Barré syndrome (GBS), the axonal subtype of which is mainly triggered by C. jejuni with ganglioside-mimicking lipooligosaccharides (LOS), is an immune-mediated disorder in the peripheral nervous system (PNS) accompanied by the disruption of the blood-nerve barrier (BNB) and the blood-cerebrospinal fluid barrier (B-CSF-B). Biomarkers of GBS have been extensively explored and some of them are proved to assist in the clinical diagnosis and in monitoring disease progression as well as in assessing the efficacy of immunotherapy. Herein, we systemically review the literature on biomarkers of GBS, including infection-/immune-/BNB, B-CSF-B, and PNS damage-associated biomarkers, aiming at providing an overview of GBS biomarkers and guiding further investigations. Furthermore, we point out further directions for studies on GBS biomarkers.http://dx.doi.org/10.1155/2015/564098 |
| spellingShingle | Ying Wang Shuang Sun Jie Zhu Li Cui Hong-Liang Zhang Biomarkers of Guillain-Barré Syndrome: Some Recent Progress, More Still to Be Explored Mediators of Inflammation |
| title | Biomarkers of Guillain-Barré Syndrome: Some Recent Progress, More Still to Be Explored |
| title_full | Biomarkers of Guillain-Barré Syndrome: Some Recent Progress, More Still to Be Explored |
| title_fullStr | Biomarkers of Guillain-Barré Syndrome: Some Recent Progress, More Still to Be Explored |
| title_full_unstemmed | Biomarkers of Guillain-Barré Syndrome: Some Recent Progress, More Still to Be Explored |
| title_short | Biomarkers of Guillain-Barré Syndrome: Some Recent Progress, More Still to Be Explored |
| title_sort | biomarkers of guillain barre syndrome some recent progress more still to be explored |
| url | http://dx.doi.org/10.1155/2015/564098 |
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