Intravenous Immunoglobulins: Mode of Action and Indications in Autoimmune and Inflammatory Dermatoses
Intravenous immunoglobulins (IVIGs), a mixture of variable amounts of proteins (albumin, IgG, IgM, IgA, and IgE antibodies), as well as salt, sugar, solvents, and detergents, are successfully used to treat a variety of dermatological disorders. For decades, IVIGs have been administered for treatment...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/3523057 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832568058740211712 |
|---|---|
| author | Lyubomir A. Dourmishev Dimitrina V. Guleva Ljubka G. Miteva |
| author_facet | Lyubomir A. Dourmishev Dimitrina V. Guleva Ljubka G. Miteva |
| author_sort | Lyubomir A. Dourmishev |
| collection | DOAJ |
| description | Intravenous immunoglobulins (IVIGs), a mixture of variable amounts of proteins (albumin, IgG, IgM, IgA, and IgE antibodies), as well as salt, sugar, solvents, and detergents, are successfully used to treat a variety of dermatological disorders. For decades, IVIGs have been administered for treatment of infectious diseases and immune deficiencies, since they contain natural antibodies that represent a first-line defense against pathogens. Today their indication has expanded, including the off-label therapy for a variety of autoimmune and inflammatory diseases. In dermatology, IVIGs are administered for treatment of different disorders at different therapeutic regimens, mostly with higher doses then those administered for treatment of infectious diseases. The aim of this prospective review is to highlight the indications, effectiveness, side effects, and perspectives of the systemic treatment with IVIGs for patients with severe, life-threatening, and resistant to conventional therapies autoimmune or inflammatory dermatoses. |
| format | Article |
| id | doaj-art-2c36588de80d48339a8d4b64348eeb73 |
| institution | Kabale University |
| issn | 2090-8040 2042-0099 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-2c36588de80d48339a8d4b64348eeb732025-02-03T00:59:45ZengWileyInternational Journal of Inflammation2090-80402042-00992016-01-01201610.1155/2016/35230573523057Intravenous Immunoglobulins: Mode of Action and Indications in Autoimmune and Inflammatory DermatosesLyubomir A. Dourmishev0Dimitrina V. Guleva1Ljubka G. Miteva2Department of Dermatology and Venereology, Medical University-Sofia, BulgariaDepartment of Dermatology and Venereology, Medical University-Sofia, BulgariaDepartment of Dermatology and Venereology, Medical University-Sofia, BulgariaIntravenous immunoglobulins (IVIGs), a mixture of variable amounts of proteins (albumin, IgG, IgM, IgA, and IgE antibodies), as well as salt, sugar, solvents, and detergents, are successfully used to treat a variety of dermatological disorders. For decades, IVIGs have been administered for treatment of infectious diseases and immune deficiencies, since they contain natural antibodies that represent a first-line defense against pathogens. Today their indication has expanded, including the off-label therapy for a variety of autoimmune and inflammatory diseases. In dermatology, IVIGs are administered for treatment of different disorders at different therapeutic regimens, mostly with higher doses then those administered for treatment of infectious diseases. The aim of this prospective review is to highlight the indications, effectiveness, side effects, and perspectives of the systemic treatment with IVIGs for patients with severe, life-threatening, and resistant to conventional therapies autoimmune or inflammatory dermatoses.http://dx.doi.org/10.1155/2016/3523057 |
| spellingShingle | Lyubomir A. Dourmishev Dimitrina V. Guleva Ljubka G. Miteva Intravenous Immunoglobulins: Mode of Action and Indications in Autoimmune and Inflammatory Dermatoses International Journal of Inflammation |
| title | Intravenous Immunoglobulins: Mode of Action and Indications in Autoimmune and Inflammatory Dermatoses |
| title_full | Intravenous Immunoglobulins: Mode of Action and Indications in Autoimmune and Inflammatory Dermatoses |
| title_fullStr | Intravenous Immunoglobulins: Mode of Action and Indications in Autoimmune and Inflammatory Dermatoses |
| title_full_unstemmed | Intravenous Immunoglobulins: Mode of Action and Indications in Autoimmune and Inflammatory Dermatoses |
| title_short | Intravenous Immunoglobulins: Mode of Action and Indications in Autoimmune and Inflammatory Dermatoses |
| title_sort | intravenous immunoglobulins mode of action and indications in autoimmune and inflammatory dermatoses |
| url | http://dx.doi.org/10.1155/2016/3523057 |
| work_keys_str_mv | AT lyubomiradourmishev intravenousimmunoglobulinsmodeofactionandindicationsinautoimmuneandinflammatorydermatoses AT dimitrinavguleva intravenousimmunoglobulinsmodeofactionandindicationsinautoimmuneandinflammatorydermatoses AT ljubkagmiteva intravenousimmunoglobulinsmodeofactionandindicationsinautoimmuneandinflammatorydermatoses |