Mechanisms and Recent Advances of Small-Molecule Therapeutics in Rosacea Treatment
Maogen Ye,1,2 Pingsheng Hao,1 Nana Luo,1 Tianhao Li1 1Department of Dermatology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610000, People’s Republic of China; 2Chengdu University of Traditional Chinese Medicine, Chengdu, 610000, People’s Republic of ChinaCorrespondence...
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Dove Medical Press
2025-06-01
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| Series: | Clinical, Cosmetic and Investigational Dermatology |
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| author | Ye M Hao P Luo N Li T |
| author_facet | Ye M Hao P Luo N Li T |
| author_sort | Ye M |
| collection | DOAJ |
| description | Maogen Ye,1,2 Pingsheng Hao,1 Nana Luo,1 Tianhao Li1 1Department of Dermatology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610000, People’s Republic of China; 2Chengdu University of Traditional Chinese Medicine, Chengdu, 610000, People’s Republic of ChinaCorrespondence: Pingsheng Hao, Department of Dermatology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610000, People’s Republic of China, Tel/Fax +86-28-87769902, Email hpswl@126.comAbstract: Rosacea is a common dermatological disease, and the complexity of its etiology and pathogenesis makes conventional treatment of rosacea difficult. Small-molecule drugs are a new option for the treatment of rosacea. Based on its good efficacy, convenience of use, affordable price and other advantages, more and more small-molecule drugs are used in the treatment and management of rosacea, involving a variety of molecular pathways, including JAK/STAT signaling pathway, TRPV, TLR2-KLK5-LL37 and mTOR pathways, Th1/Th17-IL17, PED-4, AhR and MRGPRX2. However, the specific treatment mechanism and research progress have not been systematically elucidated. This review summarizes the latest advances in small molecules targeting key inflammatory pathways in rosacea, provides new ideas for the treatment of rosacea and new directions for the clinical management of rosacea. In addition, we need to pay attention to individual differences in patients, the side effects of drugs and formulations. Therefore, further research on small-molecule drugs for the treatment of rosacea is very necessary.Keywords: rosacea, small-molecule drugs, mechanism of action |
| format | Article |
| id | doaj-art-2c2c27330c13445bbfb5409fbf8f53fc |
| institution | OA Journals |
| issn | 1178-7015 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical, Cosmetic and Investigational Dermatology |
| spelling | doaj-art-2c2c27330c13445bbfb5409fbf8f53fc2025-08-20T02:24:13ZengDove Medical PressClinical, Cosmetic and Investigational Dermatology1178-70152025-06-01Volume 18Issue 114591470103840Mechanisms and Recent Advances of Small-Molecule Therapeutics in Rosacea TreatmentYe M0Hao P1Luo N2Li T3DermatologyDermatologyDermatologyDermatologyMaogen Ye,1,2 Pingsheng Hao,1 Nana Luo,1 Tianhao Li1 1Department of Dermatology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610000, People’s Republic of China; 2Chengdu University of Traditional Chinese Medicine, Chengdu, 610000, People’s Republic of ChinaCorrespondence: Pingsheng Hao, Department of Dermatology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610000, People’s Republic of China, Tel/Fax +86-28-87769902, Email hpswl@126.comAbstract: Rosacea is a common dermatological disease, and the complexity of its etiology and pathogenesis makes conventional treatment of rosacea difficult. Small-molecule drugs are a new option for the treatment of rosacea. Based on its good efficacy, convenience of use, affordable price and other advantages, more and more small-molecule drugs are used in the treatment and management of rosacea, involving a variety of molecular pathways, including JAK/STAT signaling pathway, TRPV, TLR2-KLK5-LL37 and mTOR pathways, Th1/Th17-IL17, PED-4, AhR and MRGPRX2. However, the specific treatment mechanism and research progress have not been systematically elucidated. This review summarizes the latest advances in small molecules targeting key inflammatory pathways in rosacea, provides new ideas for the treatment of rosacea and new directions for the clinical management of rosacea. In addition, we need to pay attention to individual differences in patients, the side effects of drugs and formulations. Therefore, further research on small-molecule drugs for the treatment of rosacea is very necessary.Keywords: rosacea, small-molecule drugs, mechanism of actionhttps://www.dovepress.com/mechanisms-and-recent-advances-of-small-molecule-therapeutics-in-rosac-peer-reviewed-fulltext-article-CCIDRosaceaSmall-molecule drugsMechanism of action |
| spellingShingle | Ye M Hao P Luo N Li T Mechanisms and Recent Advances of Small-Molecule Therapeutics in Rosacea Treatment Clinical, Cosmetic and Investigational Dermatology Rosacea Small-molecule drugs Mechanism of action |
| title | Mechanisms and Recent Advances of Small-Molecule Therapeutics in Rosacea Treatment |
| title_full | Mechanisms and Recent Advances of Small-Molecule Therapeutics in Rosacea Treatment |
| title_fullStr | Mechanisms and Recent Advances of Small-Molecule Therapeutics in Rosacea Treatment |
| title_full_unstemmed | Mechanisms and Recent Advances of Small-Molecule Therapeutics in Rosacea Treatment |
| title_short | Mechanisms and Recent Advances of Small-Molecule Therapeutics in Rosacea Treatment |
| title_sort | mechanisms and recent advances of small molecule therapeutics in rosacea treatment |
| topic | Rosacea Small-molecule drugs Mechanism of action |
| url | https://www.dovepress.com/mechanisms-and-recent-advances-of-small-molecule-therapeutics-in-rosac-peer-reviewed-fulltext-article-CCID |
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