A Rare Case of Ixazomib-Induced Cutaneous Necrotizing Vasculitis in a Patient with Relapsed Myeloma
Ixazomib is the only oral proteasome inhibitor used in relapsed/refractory myeloma. Cutaneous side effects due to ixazomib have been documented in the literature; however, cutaneous necrotizing vasculitis is extremely rare. We describe a case of a 74-year-old man with relapsed multiple myeloma who w...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2019/6061484 |
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| author | Heather Katz Mina Shenouda Deena Dahshan George Sonnier Yehuda Lebowicz |
| author_facet | Heather Katz Mina Shenouda Deena Dahshan George Sonnier Yehuda Lebowicz |
| author_sort | Heather Katz |
| collection | DOAJ |
| description | Ixazomib is the only oral proteasome inhibitor used in relapsed/refractory myeloma. Cutaneous side effects due to ixazomib have been documented in the literature; however, cutaneous necrotizing vasculitis is extremely rare. We describe a case of a 74-year-old man with relapsed multiple myeloma who was started on ixazomib, lenalidomide, and dexamethasone. He developed several skin lesions that were biopsied and revealed cutaneous necrotizing vasculitis. Ixazomib was held with resolution of the vasculitic lesions and restarted with dexamethasone to 20 mg on the day of treatment and 20 mg dose the day after treatment. |
| format | Article |
| id | doaj-art-2c2664ca58824f719a6e30c0ddb791a9 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-2c2664ca58824f719a6e30c0ddb791a92025-02-03T01:29:58ZengWileyCase Reports in Hematology2090-65602090-65792019-01-01201910.1155/2019/60614846061484A Rare Case of Ixazomib-Induced Cutaneous Necrotizing Vasculitis in a Patient with Relapsed MyelomaHeather Katz0Mina Shenouda1Deena Dahshan2George Sonnier3Yehuda Lebowicz4Department of Hematology/Oncology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 500 Hofstra Blvd, Hempstead, NY 11549, USADepartment of Hematology/Oncology, Joan C. Edwards School of Medicine, Marshall University, 1600 Medical Center Dr., Huntington, WV 25701, USAJoan C. Edwards School of Medicine, Marshall University, 1600 Medical Center Dr., Huntington, WV 25701, USADepartment of Dermatology, University of Louisville School of Medicine, Louisville, KY 40203, USADepartment of Hematology/Oncology, UPMC Hillman Cancer Center, 1030 Beaver Hollow Rd., Beaver, PA 15009, USAIxazomib is the only oral proteasome inhibitor used in relapsed/refractory myeloma. Cutaneous side effects due to ixazomib have been documented in the literature; however, cutaneous necrotizing vasculitis is extremely rare. We describe a case of a 74-year-old man with relapsed multiple myeloma who was started on ixazomib, lenalidomide, and dexamethasone. He developed several skin lesions that were biopsied and revealed cutaneous necrotizing vasculitis. Ixazomib was held with resolution of the vasculitic lesions and restarted with dexamethasone to 20 mg on the day of treatment and 20 mg dose the day after treatment.http://dx.doi.org/10.1155/2019/6061484 |
| spellingShingle | Heather Katz Mina Shenouda Deena Dahshan George Sonnier Yehuda Lebowicz A Rare Case of Ixazomib-Induced Cutaneous Necrotizing Vasculitis in a Patient with Relapsed Myeloma Case Reports in Hematology |
| title | A Rare Case of Ixazomib-Induced Cutaneous Necrotizing Vasculitis in a Patient with Relapsed Myeloma |
| title_full | A Rare Case of Ixazomib-Induced Cutaneous Necrotizing Vasculitis in a Patient with Relapsed Myeloma |
| title_fullStr | A Rare Case of Ixazomib-Induced Cutaneous Necrotizing Vasculitis in a Patient with Relapsed Myeloma |
| title_full_unstemmed | A Rare Case of Ixazomib-Induced Cutaneous Necrotizing Vasculitis in a Patient with Relapsed Myeloma |
| title_short | A Rare Case of Ixazomib-Induced Cutaneous Necrotizing Vasculitis in a Patient with Relapsed Myeloma |
| title_sort | rare case of ixazomib induced cutaneous necrotizing vasculitis in a patient with relapsed myeloma |
| url | http://dx.doi.org/10.1155/2019/6061484 |
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