Improvements in pig agriculture through gene editing
Abstract Genetic modification of animals via selective breeding is the basis for modern agriculture. The current breeding paradigm however has limitations, chief among them is the requirement for the beneficial trait to exist within the population. Desirable alleles in geographically isolated breeds...
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| Format: | Article |
| Language: | English |
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CABI
2022-06-01
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| Series: | CABI Agriculture and Bioscience |
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| Online Access: | https://doi.org/10.1186/s43170-022-00111-9 |
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| author | Kristin M. Whitworth Jonathan A. Green Bethany K. Redel Rodney D. Geisert Kiho Lee Bhanu P. Telugu Kevin D. Wells Randall S. Prather |
| author_facet | Kristin M. Whitworth Jonathan A. Green Bethany K. Redel Rodney D. Geisert Kiho Lee Bhanu P. Telugu Kevin D. Wells Randall S. Prather |
| author_sort | Kristin M. Whitworth |
| collection | DOAJ |
| description | Abstract Genetic modification of animals via selective breeding is the basis for modern agriculture. The current breeding paradigm however has limitations, chief among them is the requirement for the beneficial trait to exist within the population. Desirable alleles in geographically isolated breeds, or breeds selected for a different conformation and commercial application, and more importantly animals from different genera or species cannot be introgressed into the population via selective breeding. Additionally, linkage disequilibrium results in low heritability and necessitates breeding over successive generations to fix a beneficial trait within a population. Given the need to sustainably improve animal production to feed an anticipated 9 billion global population by 2030 against a backdrop of infectious diseases and a looming threat from climate change, there is a pressing need for responsive, precise, and agile breeding strategies. The availability of genome editing tools that allow for the introduction of precise genetic modification at a single nucleotide resolution, while also facilitating large transgene integration in the target population, offers a solution. Concordant with the developments in genomic sequencing approaches, progress among germline editing efforts is expected to reach feverish pace. The current manuscript reviews past and current developments in germline engineering in pigs, and the many advantages they confer for advancing animal agriculture. |
| format | Article |
| id | doaj-art-2c1ba4aa294f4cb59638628401275d7a |
| institution | Kabale University |
| issn | 2662-4044 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | CABI |
| record_format | Article |
| series | CABI Agriculture and Bioscience |
| spelling | doaj-art-2c1ba4aa294f4cb59638628401275d7a2025-02-03T00:54:14ZengCABICABI Agriculture and Bioscience2662-40442022-06-013111610.1186/s43170-022-00111-9Improvements in pig agriculture through gene editingKristin M. Whitworth0Jonathan A. Green1Bethany K. Redel2Rodney D. Geisert3Kiho Lee4Bhanu P. Telugu5Kevin D. Wells6Randall S. Prather7Division of Animal Science, College of Agriculture Food and Natural Resources, University of MissouriDivision of Animal Science, College of Agriculture Food and Natural Resources, University of MissouriUnited States Department of Agriculture – Agriculture Research Service, Plant Genetics Research UnitDivision of Animal Science, College of Agriculture Food and Natural Resources, University of MissouriDivision of Animal Science, College of Agriculture Food and Natural Resources, University of MissouriDivision of Animal Science, College of Agriculture Food and Natural Resources, University of MissouriDivision of Animal Science, College of Agriculture Food and Natural Resources, University of MissouriDivision of Animal Science, College of Agriculture Food and Natural Resources, University of MissouriAbstract Genetic modification of animals via selective breeding is the basis for modern agriculture. The current breeding paradigm however has limitations, chief among them is the requirement for the beneficial trait to exist within the population. Desirable alleles in geographically isolated breeds, or breeds selected for a different conformation and commercial application, and more importantly animals from different genera or species cannot be introgressed into the population via selective breeding. Additionally, linkage disequilibrium results in low heritability and necessitates breeding over successive generations to fix a beneficial trait within a population. Given the need to sustainably improve animal production to feed an anticipated 9 billion global population by 2030 against a backdrop of infectious diseases and a looming threat from climate change, there is a pressing need for responsive, precise, and agile breeding strategies. The availability of genome editing tools that allow for the introduction of precise genetic modification at a single nucleotide resolution, while also facilitating large transgene integration in the target population, offers a solution. Concordant with the developments in genomic sequencing approaches, progress among germline editing efforts is expected to reach feverish pace. The current manuscript reviews past and current developments in germline engineering in pigs, and the many advantages they confer for advancing animal agriculture.https://doi.org/10.1186/s43170-022-00111-9Gene editingCRISPR/CasSwineAgriculture |
| spellingShingle | Kristin M. Whitworth Jonathan A. Green Bethany K. Redel Rodney D. Geisert Kiho Lee Bhanu P. Telugu Kevin D. Wells Randall S. Prather Improvements in pig agriculture through gene editing CABI Agriculture and Bioscience Gene editing CRISPR/Cas Swine Agriculture |
| title | Improvements in pig agriculture through gene editing |
| title_full | Improvements in pig agriculture through gene editing |
| title_fullStr | Improvements in pig agriculture through gene editing |
| title_full_unstemmed | Improvements in pig agriculture through gene editing |
| title_short | Improvements in pig agriculture through gene editing |
| title_sort | improvements in pig agriculture through gene editing |
| topic | Gene editing CRISPR/Cas Swine Agriculture |
| url | https://doi.org/10.1186/s43170-022-00111-9 |
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