Impact of Topical Nepafenac on Macular Thickness after Phacoemulsification with Intraocular Lens Implantation in Patients without Diabetic Retinopathy
Objective: To study the effect of post-operative Non-Steroidal Anti-inflammatory (NSAID) eye drops on macular thickness in patients without diabetic retinopathy measured by Optical Coherence Tomography (OCT) after cataract surgery. Study Design: Quasi-experimental study. Place & Duration of S...
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Rawalpindi Medical University
2023-01-01
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| Series: | Journal of Rawalpindi Medical College |
| Online Access: | https://www.journalrmc.com/index.php/JRMC/article/view/1877 |
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| author | Arooj Amjad, Muhammad Shaheer, Hassan Tariq, Ammarah Rasheed Arooj Amjad, Muhammad Shaheer, Hassan Tariq, Ammarah Rasheed |
| author_facet | Arooj Amjad, Muhammad Shaheer, Hassan Tariq, Ammarah Rasheed Arooj Amjad, Muhammad Shaheer, Hassan Tariq, Ammarah Rasheed |
| author_sort | Arooj Amjad, Muhammad Shaheer, Hassan Tariq, Ammarah Rasheed Arooj Amjad, Muhammad Shaheer, Hassan Tariq, Ammarah Rasheed |
| collection | DOAJ |
| description |
Objective: To study the effect of post-operative Non-Steroidal Anti-inflammatory (NSAID) eye drops on macular
thickness in patients without diabetic retinopathy measured by Optical Coherence Tomography (OCT) after
cataract surgery.
Study Design: Quasi-experimental study.
Place & Duration of Study: Ophthalmology Department/Lahore General Hospital, Lahore from 15-01-2019 to
31-12-2021.
Materials & Methods: Diabetic patients without retinopathy who required cataract surgery for visual
rehabilitation were included in the study. They were then divided into two groups. Group A included patients
who received routine steroid+antibiotic post-operative drops while Group B comprised patients who received
nepafenac (0.1%) eye drops eight hourly in addition to routine post-operative eye drops. All patients underwent
standard phacoemulsification and intraocular lens implantation followed by the use of NSAID eye drops for a
month. OCT measurements were done pre-operatively, 7 and 28 days post-operatively.
Results: Comparison of central macular thickness between groups was significant at (Pre & 7-day post-op) and
insignificant at (7th day & 28th day post-op) and (Pre & 28th day post op) i.e. 0.043, 0.834, and 0.084 respectively.
However, a difference in mean central macular thickness was significant in all follow-up periods i.e. 0.003, 0.006,
and 0.000
Conclusion: Post-operative NSAID in diabetic patients without retinopathy leads to a significant decrease in
macular thickness as compared to those who do not receive post-operative NSAID after cataract surgery.
Keywords: Phacoemulsification, Optical Coherence Tomography, Non-steroidal Anti-Inflammatory Agents.
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| format | Article |
| id | doaj-art-2c100d9e7d6d4d6cbc00901c86088b5c |
| institution | Kabale University |
| issn | 1683-3562 1683-3570 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Rawalpindi Medical University |
| record_format | Article |
| series | Journal of Rawalpindi Medical College |
| spelling | doaj-art-2c100d9e7d6d4d6cbc00901c86088b5c2025-02-06T08:44:03ZengRawalpindi Medical UniversityJournal of Rawalpindi Medical College1683-35621683-35702023-01-0126210.37939/jrmc.v26i2.1877Impact of Topical Nepafenac on Macular Thickness after Phacoemulsification with Intraocular Lens Implantation in Patients without Diabetic RetinopathyArooj Amjad, Muhammad Shaheer, Hassan Tariq, Ammarah Rasheed Arooj Amjad, Muhammad Shaheer, Hassan Tariq, Ammarah Rasheed Objective: To study the effect of post-operative Non-Steroidal Anti-inflammatory (NSAID) eye drops on macular thickness in patients without diabetic retinopathy measured by Optical Coherence Tomography (OCT) after cataract surgery. Study Design: Quasi-experimental study. Place & Duration of Study: Ophthalmology Department/Lahore General Hospital, Lahore from 15-01-2019 to 31-12-2021. Materials & Methods: Diabetic patients without retinopathy who required cataract surgery for visual rehabilitation were included in the study. They were then divided into two groups. Group A included patients who received routine steroid+antibiotic post-operative drops while Group B comprised patients who received nepafenac (0.1%) eye drops eight hourly in addition to routine post-operative eye drops. All patients underwent standard phacoemulsification and intraocular lens implantation followed by the use of NSAID eye drops for a month. OCT measurements were done pre-operatively, 7 and 28 days post-operatively. Results: Comparison of central macular thickness between groups was significant at (Pre & 7-day post-op) and insignificant at (7th day & 28th day post-op) and (Pre & 28th day post op) i.e. 0.043, 0.834, and 0.084 respectively. However, a difference in mean central macular thickness was significant in all follow-up periods i.e. 0.003, 0.006, and 0.000 Conclusion: Post-operative NSAID in diabetic patients without retinopathy leads to a significant decrease in macular thickness as compared to those who do not receive post-operative NSAID after cataract surgery. Keywords: Phacoemulsification, Optical Coherence Tomography, Non-steroidal Anti-Inflammatory Agents. https://www.journalrmc.com/index.php/JRMC/article/view/1877 |
| spellingShingle | Arooj Amjad, Muhammad Shaheer, Hassan Tariq, Ammarah Rasheed Arooj Amjad, Muhammad Shaheer, Hassan Tariq, Ammarah Rasheed Impact of Topical Nepafenac on Macular Thickness after Phacoemulsification with Intraocular Lens Implantation in Patients without Diabetic Retinopathy Journal of Rawalpindi Medical College |
| title | Impact of Topical Nepafenac on Macular Thickness after Phacoemulsification with Intraocular Lens Implantation in Patients without Diabetic Retinopathy |
| title_full | Impact of Topical Nepafenac on Macular Thickness after Phacoemulsification with Intraocular Lens Implantation in Patients without Diabetic Retinopathy |
| title_fullStr | Impact of Topical Nepafenac on Macular Thickness after Phacoemulsification with Intraocular Lens Implantation in Patients without Diabetic Retinopathy |
| title_full_unstemmed | Impact of Topical Nepafenac on Macular Thickness after Phacoemulsification with Intraocular Lens Implantation in Patients without Diabetic Retinopathy |
| title_short | Impact of Topical Nepafenac on Macular Thickness after Phacoemulsification with Intraocular Lens Implantation in Patients without Diabetic Retinopathy |
| title_sort | impact of topical nepafenac on macular thickness after phacoemulsification with intraocular lens implantation in patients without diabetic retinopathy |
| url | https://www.journalrmc.com/index.php/JRMC/article/view/1877 |
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