Mitochondrial Stress Signaling Promotes Cellular Adaptations
Mitochondrial dysfunction has been implicated in the aetiology of many complex diseases, as well as the ageing process. Much of the research on mitochondrial dysfunction has focused on how mitochondrial damage may potentiate pathological phenotypes. The purpose of this review is to draw attention to...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2014/156020 |
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| _version_ | 1832551936451149824 |
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| author | Jayne Alexandra Barbour Nigel Turner |
| author_facet | Jayne Alexandra Barbour Nigel Turner |
| author_sort | Jayne Alexandra Barbour |
| collection | DOAJ |
| description | Mitochondrial dysfunction has been implicated in the aetiology of many complex diseases, as well as the ageing process. Much of the research on mitochondrial dysfunction has focused on how mitochondrial damage may potentiate pathological phenotypes. The purpose of this review is to draw attention to the less well-studied mechanisms by which the cell adapts to mitochondrial perturbations. This involves communication of stress to the cell and successful induction of quality control responses, which include mitophagy, unfolded protein response, upregulation of antioxidant and DNA repair enzymes, morphological changes, and if all else fails apoptosis. The mitochondrion is an inherently stressful environment and we speculate that dysregulation of stress signaling or an inability to switch on these adaptations during times of mitochondrial stress may underpin mitochondrial dysfunction and hence amount to pathological states over time. |
| format | Article |
| id | doaj-art-2c0c24fc9bab47769ad876ed94fcd144 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-2c0c24fc9bab47769ad876ed94fcd1442025-02-03T06:00:05ZengWileyInternational Journal of Cell Biology1687-88761687-88842014-01-01201410.1155/2014/156020156020Mitochondrial Stress Signaling Promotes Cellular AdaptationsJayne Alexandra Barbour0Nigel Turner1Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, AustraliaDepartment of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, AustraliaMitochondrial dysfunction has been implicated in the aetiology of many complex diseases, as well as the ageing process. Much of the research on mitochondrial dysfunction has focused on how mitochondrial damage may potentiate pathological phenotypes. The purpose of this review is to draw attention to the less well-studied mechanisms by which the cell adapts to mitochondrial perturbations. This involves communication of stress to the cell and successful induction of quality control responses, which include mitophagy, unfolded protein response, upregulation of antioxidant and DNA repair enzymes, morphological changes, and if all else fails apoptosis. The mitochondrion is an inherently stressful environment and we speculate that dysregulation of stress signaling or an inability to switch on these adaptations during times of mitochondrial stress may underpin mitochondrial dysfunction and hence amount to pathological states over time.http://dx.doi.org/10.1155/2014/156020 |
| spellingShingle | Jayne Alexandra Barbour Nigel Turner Mitochondrial Stress Signaling Promotes Cellular Adaptations International Journal of Cell Biology |
| title | Mitochondrial Stress Signaling Promotes Cellular Adaptations |
| title_full | Mitochondrial Stress Signaling Promotes Cellular Adaptations |
| title_fullStr | Mitochondrial Stress Signaling Promotes Cellular Adaptations |
| title_full_unstemmed | Mitochondrial Stress Signaling Promotes Cellular Adaptations |
| title_short | Mitochondrial Stress Signaling Promotes Cellular Adaptations |
| title_sort | mitochondrial stress signaling promotes cellular adaptations |
| url | http://dx.doi.org/10.1155/2014/156020 |
| work_keys_str_mv | AT jaynealexandrabarbour mitochondrialstresssignalingpromotescellularadaptations AT nigelturner mitochondrialstresssignalingpromotescellularadaptations |