Tomatidine Attenuates Airway Hyperresponsiveness and Inflammation by Suppressing Th2 Cytokines in a Mouse Model of Asthma

Tomatidine Attenuates Airway Hyperresponsiveness and Inflammation by Suppressing Th2 Cytokines in a Mouse Model of Asthma

Tomatidine is isolated from the fruits of tomato plants and found to have anti-inflammatory effects in macrophages. In the present study, we investigated whether tomatidine suppresses airway hyperresponsiveness (AHR) and eosinophil infiltration in asthmatic mice. BALB/c mice were sensitized with ova...

Full description

Saved in:

Bibliographic Details
Main Authors:	Chieh-Ying Kuo, Wen-Chung Huang, Chian-Jiun Liou, Li-Chen Chen, Jiann-Jong Shen, Ming-Ling Kuo
Format:	Article
Language:	English
Published:	Wiley 2017-01-01
Series:	Mediators of Inflammation
Online Access:	http://dx.doi.org/10.1155/2017/5261803
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Helminthostachys zeylanica Water Extract Ameliorates Airway Hyperresponsiveness and Eosinophil Infiltration by Reducing Oxidative Stress and Th2 Cytokine Production in a Mouse Asthma Model
by: Wen-Chung Huang, et al.
Published: (2020-01-01)

Prevalence of airway hyperresponsiveness and its seasonal variation in children with asthma
by: Shu-Jung Huang, et al.
Published: (2018-12-01)

Airway hyperresponsiveness in bronchial asthma: pathogenesis basics
by: I. A. Deyev, et al.
Published: (2002-12-01)

Kiss1 receptor knockout exacerbates airway hyperresponsiveness and remodeling in a mouse model of allergic asthma
by: Nilesh Sudhakar Ambhore, et al.
Published: (2024-10-01)

Exacerbation of asthma and neutrophil-dominated airway inflammation in patients with cold-induced airway hyperresponsiveness
by: A. B. Pirogov, et al.
Published: (2021-07-01)

Pinellia ternata, Citrus reticulata, and Their Combinational Prescription Inhibit Eosinophil Infiltration and Airway Hyperresponsiveness by Suppressing CCR3+ and Th2 Cytokines Production in the Ovalbumin-Induced Asthma Model
by: In-Soo Ok, et al.
Published: (2009-01-01)

Interleukin-4 and interferon gamma in bronchial remodeling in asthma patients with cold airway hyperresponsiveness
by: A. B. Pirogov, et al.
Published: (2025-04-01)

Evaluating serum periostin and YKL-40 as biomarkers for airway remodeling and hyperresponsiveness in pediatric asthma
by: Su Ji Kim, MD, et al.
Published: (2024-11-01)

The Expression of Semaphorin3E in Vagal Ganglion and Lung Tissue Is Related to Airway Hyperresponsiveness in Murine Asthma Model
by: Liyan Chen, et al.
Published: (2023-01-01)

Airway inflammation, bronchial hyperresponsiveness, and anti-asthma therapy responses in cough variant asthma and classic asthma with FEV1% ≥80% predicted
by: Xue Zhang, et al.
Published: (2025-04-01)

The MIF Antagonist ISO-1 Attenuates Corticosteroid-Insensitive Inflammation and Airways Hyperresponsiveness in an Ozone-Induced Model of COPD.
by: Kirsty E Russell, et al.
Published: (2016-01-01)

Inhibitory Effects of Phellodendri Cortex Against Airway Inflammation and Hyperresponsiveness in Ovalbumin-Induced Murine Asthma Model
by: Seong-Kyeom Kim, et al.
Published: (2025-04-01)

Predicting airway hyperresponsiveness to methacholine in patients with atopic dermatitis
by: Ruth P. Cusack, MD, et al.
Published: (2025-08-01)

Clinical and pathogenetic aspects of neutrophilic bronchial inflammation in asthma patients with cold-induced airway hyperresponsiveness (literature review)
by: A. B. Pirogov, et al.
Published: (2023-04-01)

Bronchial granulocytes in the development of epithelial destruction and oxidative lipid modification in patients with bronchial asthma with cold and osmotic airway hyperresponsiveness
by: A. B. Pirogov, et al.
Published: (2021-04-01)

Allergen uptake, activation, and IL-23 production by pulmonary myeloid DCs drives airway hyperresponsiveness in asthma-susceptible mice.
by: Ian P Lewkowich, et al.
Published: (2008-01-01)

The effect of childhood obesity on respiratory function tests and airway hyperresponsiveness
by: Zülal Ulger, et al.
Published: (2006-01-01)

Early childhood lower-airway symptoms and airway hyperresponsiveness linked to school-age small-airway dysfunction
by: Anette M. Määttä, MD, et al.
Published: (2025-05-01)

Cytokines reprogram airway sensory neurons in asthma
by: Theo Crosson, et al.
Published: (2024-12-01)

The influence of smoking on the formation of airway hyperresponsiveness to cold and the course of destructive-cytological processes in the goblet cells of the bronchial epithelium in patients with asthma
by: A. B. Pirogov, et al.
Published: (2019-10-01)

Reduced Airway Hyperresponsiveness by Phosphodiesterase 3 and 4 Inhibitors in Guinea-Pigs
by: Nöella Germain, et al.
Published: (1999-01-01)

Efficiency of using a short-acting β2-agonist for the relief of acute cold bronchospasm in asthma patients with cold airway hyperresponsiveness
by: A. G. Prihodko, et al.
Published: (2022-10-01)

Toll-like receptor activation induces airway obstruction and hyperresponsiveness in guinea pigs
by: Yujiao Xiang, et al.
Published: (2024-11-01)

Correlation between tidal breathing pulmonary function, exhaled nitric oxide and airway hyperresponsiveness in children aged 0–3 years with suspected asthma
by: Jiangjiao Qin, et al.
Published: (2025-07-01)

Effects of Radix Adenophorae and Cyclosporine A on an OVA-Induced Murine Model of Asthma by Suppressing to T Cells Activity, Eosinophilia, and Bronchial Hyperresponsiveness
by: Seong-Soo Roh, et al.
Published: (2008-01-01)

Infants born during COVID-19 pandemic experience increased susceptibility to airway hyperresponsiveness
by: Idit Lachover-Roth, et al.
Published: (2024-12-01)

Efficacy of Inhaled Corticosteroids in Patients with Bronchiectasis without Airway Hyperresponsiveness: A Pilot Study
by: Safia Ahmed, et al.
Published: (2024-11-01)

The dichotomous impacts of Semaphorin3E deficiency on exacerbating airway hyperresponsiveness, remodelling, and inflammation in type-2 low and type-2 high asthma models.
by: Mojdeh Matloubi, et al.
Published: (2025-01-01)

The dichotomous impacts of Semaphorin3E deficiency on exacerbating airway hyperresponsiveness, remodelling, and inflammation in type-2 low and type-2 high asthma models
by: Mojdeh Matloubi, et al.
Published: (2025-01-01)

Innovative machine learning-based prediction of early airway hyperresponsiveness using baseline pulmonary function parameters
by: Hua Yang, et al.
Published: (2025-08-01)

Obesity increases airway hyperresponsiveness via the TNF-α pathway and treating obesity induces recovery.
by: Joo Young Kim, et al.
Published: (2015-01-01)

Essential role of Card11 in airway hyperresponsiveness in high-fat diet-induced obese mice
by: Hyun-Seung Lee, et al.
Published: (2024-12-01)

Asian sand dust exacerbates airway inflammation in a mouse model of asthma
by: Se-Jin Lee, et al.
Published: (2025-05-01)

Perilla Leaf Extract Attenuates Asthma Airway Inflammation by Blocking the Syk Pathway
by: Hui Yang, et al.
Published: (2021-01-01)

Tomatidine Alleviates Intervertebral Disc Degeneration by Activating the Nrf2/HO-1/GPX4 Signaling Pathway
by: Li Z, et al.
Published: (2024-12-01)

Effects of Neutrophil-Activating Protein of Helicobacter pylori on Th Cytokines and Airway Inflammation in Allergic Asthma
by: Alireza Khaleghi Khorrami, et al.
Published: (2025-03-01)

Effects of the Immunomodulatory Agent Cordyceps militaris on Airway Inflammation in a Mouse Asthma Model
by: Chia-Hsiu Hsu, et al.
Published: (2008-10-01)

Airway Microbiota in Severe Asthma and Relationship to Asthma Severity and Phenotypes.
by: Qingling Zhang, et al.
Published: (2016-01-01)

Immunomodulatory effects of type II arabinogalactans fraction from Anoectochilus formosanus in a murine model of OVA-induced airway hyperresponsiveness
by: Yi-Lun Huang, et al.
Published: (2025-06-01)

Effect of Selective Cysteinyl Leukotriene Receptor Antagonists on Airway Inflammation and Matrix Metalloproteinase Expression in a Mouse Asthma Model
by: Chia-Hsiu Hsu, et al.
Published: (2012-08-01)