Prion forensics: a multidisciplinary approach to investigate CWD at an illegal deer carcass disposal site
Infectious prions are resistant to degradation and remain infectious in the environment for several years. Chronic wasting disease (CWD) has been detected in cervids inhabiting North America, the Nordic countries, and South Korea. CWD-prion spread is partially attributed to carcass transport and dis...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Prion |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19336896.2024.2343298 |
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| author | Marc D. Schwabenlander Jason C. Bartz Michelle Carstensen Alberto Fameli Linda Glaser Roxanne J. Larsen Manci Li Rachel L. Shoemaker Gage Rowden Suzanne Stone W. David Walter Tiffany M. Wolf Peter A. Larsen |
| author_facet | Marc D. Schwabenlander Jason C. Bartz Michelle Carstensen Alberto Fameli Linda Glaser Roxanne J. Larsen Manci Li Rachel L. Shoemaker Gage Rowden Suzanne Stone W. David Walter Tiffany M. Wolf Peter A. Larsen |
| author_sort | Marc D. Schwabenlander |
| collection | DOAJ |
| description | Infectious prions are resistant to degradation and remain infectious in the environment for several years. Chronic wasting disease (CWD) has been detected in cervids inhabiting North America, the Nordic countries, and South Korea. CWD-prion spread is partially attributed to carcass transport and disposal. We employed a forensic approach to investigate an illegal carcass dump site connected with a CWD-positive herd. We integrated anatomic, genetic, and prion amplification methods to discover CWD-positive remains from six white-tailed deer (Odocoileus virginianus) and, using microsatellite markers, confirmed a portion originated from the CWD-infected herd. This approach provides a foundation for future studies of carcass prion transmission risk. |
| format | Article |
| id | doaj-art-2bfb0fd4908a4a4c933cc02e9bbf9782 |
| institution | Kabale University |
| issn | 1933-6896 1933-690X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Prion |
| spelling | doaj-art-2bfb0fd4908a4a4c933cc02e9bbf97822025-02-05T12:40:51ZengTaylor & Francis GroupPrion1933-68961933-690X2024-12-01181728610.1080/19336896.2024.2343298Prion forensics: a multidisciplinary approach to investigate CWD at an illegal deer carcass disposal siteMarc D. Schwabenlander0Jason C. Bartz1Michelle Carstensen2Alberto Fameli3Linda Glaser4Roxanne J. Larsen5Manci Li6Rachel L. Shoemaker7Gage Rowden8Suzanne Stone9W. David Walter10Tiffany M. Wolf11Peter A. Larsen12Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN, USAMinnesota Center for Prion Research and Outreach, College of Veterinary Medicine, University of Minnesota, St. Paul, MN, USADepartment of Medical Microbiology and Immunology, School of Medicine, Creighton University, Omaha, NE, USAMinnesota Department of Natural Resources, Wildlife Health Program, Forest Lake, MN, USAPennsylvania Cooperative Fish & Wildlife Research Unit, The Pennsylvania State University, University Park, PA, USADepartment of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN, USADepartment of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN, USADepartment of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN, USADepartment of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN, USADepartment of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN, USAMinnesota Board of Animal Health, Farmed Cervidae Program, St. Paul, MN, USAU.S. Geological Survey, Pennsylvania Cooperative Fish and Wildlife Research Unit, The Pennsylvania State University, University Park, PA, USADepartment of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN, USAInfectious prions are resistant to degradation and remain infectious in the environment for several years. Chronic wasting disease (CWD) has been detected in cervids inhabiting North America, the Nordic countries, and South Korea. CWD-prion spread is partially attributed to carcass transport and disposal. We employed a forensic approach to investigate an illegal carcass dump site connected with a CWD-positive herd. We integrated anatomic, genetic, and prion amplification methods to discover CWD-positive remains from six white-tailed deer (Odocoileus virginianus) and, using microsatellite markers, confirmed a portion originated from the CWD-infected herd. This approach provides a foundation for future studies of carcass prion transmission risk.https://www.tandfonline.com/doi/10.1080/19336896.2024.2343298Cervidchronic wasting diseaseecologyenvironmentgeneticstransmission |
| spellingShingle | Marc D. Schwabenlander Jason C. Bartz Michelle Carstensen Alberto Fameli Linda Glaser Roxanne J. Larsen Manci Li Rachel L. Shoemaker Gage Rowden Suzanne Stone W. David Walter Tiffany M. Wolf Peter A. Larsen Prion forensics: a multidisciplinary approach to investigate CWD at an illegal deer carcass disposal site Prion Cervid chronic wasting disease ecology environment genetics transmission |
| title | Prion forensics: a multidisciplinary approach to investigate CWD at an illegal deer carcass disposal site |
| title_full | Prion forensics: a multidisciplinary approach to investigate CWD at an illegal deer carcass disposal site |
| title_fullStr | Prion forensics: a multidisciplinary approach to investigate CWD at an illegal deer carcass disposal site |
| title_full_unstemmed | Prion forensics: a multidisciplinary approach to investigate CWD at an illegal deer carcass disposal site |
| title_short | Prion forensics: a multidisciplinary approach to investigate CWD at an illegal deer carcass disposal site |
| title_sort | prion forensics a multidisciplinary approach to investigate cwd at an illegal deer carcass disposal site |
| topic | Cervid chronic wasting disease ecology environment genetics transmission |
| url | https://www.tandfonline.com/doi/10.1080/19336896.2024.2343298 |
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