Patchoulene epoxide mitigates colitis and hepatic damage induced by dextran sulfate sodium by regulating the colonic microbiota and purine metabolism

Patchoulene epoxide mitigates colitis and hepatic damage induced by dextran sulfate sodium by regulating the colonic microbiota and purine metabolism

IntroductionUlcerative colitis (UC) is often characterized by dysbiosis of the colonic microbiota and metabolic disturbances, which can lead to liver damage. Patchoulene epoxide (PAO), a tricyclic sesquiterpene derived from the aged essential oil of Pogostemonis Herba, is known for its anti-inflamma...

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Bibliographic Details
Main Authors: Liping Chen, Lili Xie, Lifen Wang, Xueli Zhan, Zhenjian Zhuo, Susu Jiang, Lei Miao, Xinxin Zhang, Weiming Zheng, Tzu-Ming Liu, Jing He, Yuhong Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
patchoulene epoxide
ulcerative colitis
liver injury
colonic microbiota
purine metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1509114/full
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