NTRK1-fusion as an acquired resistance mechanism in EGFRex19 mutated NSCLC: a case report

NTRK1-fusion as an acquired resistance mechanism in EGFRex19 mutated NSCLC: a case report

IntroductionA 73-year-old Chinese woman with no smoking history was diagnosed with stage IV adenocarcinoma of the lung in August 2020, presenting with left chest pain and multiple lung lesions.Patient concernsThe patient experienced chest pain for 2 months before diagnosis. Initial CT scans revealed...

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Bibliographic Details
Main Authors: Jielin Li, Yunyun Shi, Mengge Zheng, Chenkang Yang, Hong Gao, Xiaoling Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
EGFR-mutated NSCLC
NTRK-fusion
larotrectinib
resistance
case report
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1571777/full
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