Predictive Ability of Visit-to-Visit Variability of HbA1c Measurements for the Development of Diabetic Kidney Disease: A Retrospective Longitudinal Observational Study
Aims. This study is aimed at clarifying the relationship between visit-to-visit variability of glycated hemoglobin (HbA1c) and the risk of diabetic kidney disease (DKD) and to identifying the most useful index of visit-to-visit variability of HbA1c. Methods. This clinic-based retrospective longitudi...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2022/6934188 |
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| author | Yunyi Yan Nozomi Kondo Kentaro Oniki Hiroshi Watanabe Tadashi Imafuku Yuki Sakamoto Takuro Shigaki Akari Maruyama Hitomi Nakazawa Tetsuya Kaneko Ayami Morita Akira Yoshida Hitoshi Maeda Toru Maruyama Hideaki Jinnouchi Junji Saruwatari |
| author_facet | Yunyi Yan Nozomi Kondo Kentaro Oniki Hiroshi Watanabe Tadashi Imafuku Yuki Sakamoto Takuro Shigaki Akari Maruyama Hitomi Nakazawa Tetsuya Kaneko Ayami Morita Akira Yoshida Hitoshi Maeda Toru Maruyama Hideaki Jinnouchi Junji Saruwatari |
| author_sort | Yunyi Yan |
| collection | DOAJ |
| description | Aims. This study is aimed at clarifying the relationship between visit-to-visit variability of glycated hemoglobin (HbA1c) and the risk of diabetic kidney disease (DKD) and to identifying the most useful index of visit-to-visit variability of HbA1c. Methods. This clinic-based retrospective longitudinal study included 699 Japanese type 2 diabetes mellitus patients. Visit-to-visit variability of HbA1c was calculated as the internal standard deviation of HbA1c (HbA1c-SD), the coefficient of variation of HbA1c (HbA1c-CV), the HbA1c change score (HbA1c-HVS), and the area under the HbA1c curve (HbA1c-AUC) with 3-year serial HbA1c measurement data, and the associations between these indices and the development/progression of DKD were examined. Results. Cox proportional hazards models showed that the HbA1c-SD and HbA1c-AUC were associated with the incidence of microalbuminuria, independently of the HbA1c level. These results were verified and replicated in propensity score (PS) matching and bootstrap analyses. Moreover, the HbA1c-SD and HbA1c-AUC were also associated with oxidized human serum albumin (HSA), an oxidative stress marker. Conclusions. Visit-to-visit variability of HbA1c was an independent risk factor of microalbuminuria in association with oxidative stress among type 2 diabetes mellitus patients. HbA1c-AUC, a novel index of HbA1c variability, may be a potent prognostic indicator in predicting the risk of microalbuminuria. |
| format | Article |
| id | doaj-art-2bdfc3ad83ac413495f250d6a5f5b6e6 |
| institution | Kabale University |
| issn | 2314-6753 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-2bdfc3ad83ac413495f250d6a5f5b6e62025-02-03T06:11:18ZengWileyJournal of Diabetes Research2314-67532022-01-01202210.1155/2022/6934188Predictive Ability of Visit-to-Visit Variability of HbA1c Measurements for the Development of Diabetic Kidney Disease: A Retrospective Longitudinal Observational StudyYunyi Yan0Nozomi Kondo1Kentaro Oniki2Hiroshi Watanabe3Tadashi Imafuku4Yuki Sakamoto5Takuro Shigaki6Akari Maruyama7Hitomi Nakazawa8Tetsuya Kaneko9Ayami Morita10Akira Yoshida11Hitoshi Maeda12Toru Maruyama13Hideaki Jinnouchi14Junji Saruwatari15Division of Pharmacology and TherapeuticsDivision of Pharmacology and TherapeuticsDivision of Pharmacology and TherapeuticsDepartment of BiopharmaceuticsDepartment of Molecular PathophysiologyDivision of Pharmacology and TherapeuticsDivision of Pharmacology and TherapeuticsDivision of Pharmacology and TherapeuticsDivision of Pharmacology and TherapeuticsDivision of Pharmacology and TherapeuticsDiabetes Care CenterDiabetes Care CenterDepartment of BiopharmaceuticsDepartment of BiopharmaceuticsDiabetes Care CenterDivision of Pharmacology and TherapeuticsAims. This study is aimed at clarifying the relationship between visit-to-visit variability of glycated hemoglobin (HbA1c) and the risk of diabetic kidney disease (DKD) and to identifying the most useful index of visit-to-visit variability of HbA1c. Methods. This clinic-based retrospective longitudinal study included 699 Japanese type 2 diabetes mellitus patients. Visit-to-visit variability of HbA1c was calculated as the internal standard deviation of HbA1c (HbA1c-SD), the coefficient of variation of HbA1c (HbA1c-CV), the HbA1c change score (HbA1c-HVS), and the area under the HbA1c curve (HbA1c-AUC) with 3-year serial HbA1c measurement data, and the associations between these indices and the development/progression of DKD were examined. Results. Cox proportional hazards models showed that the HbA1c-SD and HbA1c-AUC were associated with the incidence of microalbuminuria, independently of the HbA1c level. These results were verified and replicated in propensity score (PS) matching and bootstrap analyses. Moreover, the HbA1c-SD and HbA1c-AUC were also associated with oxidized human serum albumin (HSA), an oxidative stress marker. Conclusions. Visit-to-visit variability of HbA1c was an independent risk factor of microalbuminuria in association with oxidative stress among type 2 diabetes mellitus patients. HbA1c-AUC, a novel index of HbA1c variability, may be a potent prognostic indicator in predicting the risk of microalbuminuria.http://dx.doi.org/10.1155/2022/6934188 |
| spellingShingle | Yunyi Yan Nozomi Kondo Kentaro Oniki Hiroshi Watanabe Tadashi Imafuku Yuki Sakamoto Takuro Shigaki Akari Maruyama Hitomi Nakazawa Tetsuya Kaneko Ayami Morita Akira Yoshida Hitoshi Maeda Toru Maruyama Hideaki Jinnouchi Junji Saruwatari Predictive Ability of Visit-to-Visit Variability of HbA1c Measurements for the Development of Diabetic Kidney Disease: A Retrospective Longitudinal Observational Study Journal of Diabetes Research |
| title | Predictive Ability of Visit-to-Visit Variability of HbA1c Measurements for the Development of Diabetic Kidney Disease: A Retrospective Longitudinal Observational Study |
| title_full | Predictive Ability of Visit-to-Visit Variability of HbA1c Measurements for the Development of Diabetic Kidney Disease: A Retrospective Longitudinal Observational Study |
| title_fullStr | Predictive Ability of Visit-to-Visit Variability of HbA1c Measurements for the Development of Diabetic Kidney Disease: A Retrospective Longitudinal Observational Study |
| title_full_unstemmed | Predictive Ability of Visit-to-Visit Variability of HbA1c Measurements for the Development of Diabetic Kidney Disease: A Retrospective Longitudinal Observational Study |
| title_short | Predictive Ability of Visit-to-Visit Variability of HbA1c Measurements for the Development of Diabetic Kidney Disease: A Retrospective Longitudinal Observational Study |
| title_sort | predictive ability of visit to visit variability of hba1c measurements for the development of diabetic kidney disease a retrospective longitudinal observational study |
| url | http://dx.doi.org/10.1155/2022/6934188 |
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