Integrin factor (FAM27E3), as a metastatic marker of papillary thyroid carcinoma, through the p53 signaling pathway promoting lymph node metastasis

Integrin factor (FAM27E3), as a metastatic marker of papillary thyroid carcinoma, through the p53 signaling pathway promoting lymph node metastasis

BackgroundPapillary thyroid carcinoma (PTC) has a lymph node metastasis rate of 20%–90%. This study aims to explore the role and regulatory mechanism of the FAM27E3 in PTC lymph node metastasis.MethodThe seven thyroid cancer (THCA) datasets from the Gene Expression Omnibus (GEO) were combined as the...

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Bibliographic Details
Main Authors: Dong Zhang, Kai-Fang Xiang, Chen-Chen Hong, Xiao-Ping Bao, Yan Wu, Rui Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Genetics
Subjects:
FAM27E3
PTC
lymph node metastasis
p53
macrophage
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2025.1593553/full
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