Comparative analysis of isoxazoline activity on human and canine GABA receptors expressed in Xenopus oocytes

Abstract Background Isoxazolines, including sarolaner, lotilaner, afoxolaner and fluralaner, are a class of ectoparasiticides that target gamma-aminobutyric acid receptors (GABARs) in insects and acari. However, their potential action on mammalian GABARs has not been extensively compared. Methods Th...

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Bibliographic Details
Main Authors: Heinz Sager, Anouk Sarr, Emmanuelle Kuntz, Lucien Rufener
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Parasites & Vectors
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Online Access:https://doi.org/10.1186/s13071-025-06847-3
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