Neuroblastoma Soft Tissue Metastasis in a 10-Month-Old Infant with a Right Thigh Mass
Background. Neuroblastoma is a solid tumor that occurs more frequently in pediatric populations. It may originate from any part of the sympathetic nervous system, but it most commonly arises from the paraspinal sympathetic ganglia in the abdomen or mediastinum. Local lymphadenopathy and distant meta...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2021/3226319 |
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| author | Shokouh Taghipour Zahir Fateme Salemi |
| author_facet | Shokouh Taghipour Zahir Fateme Salemi |
| author_sort | Shokouh Taghipour Zahir |
| collection | DOAJ |
| description | Background. Neuroblastoma is a solid tumor that occurs more frequently in pediatric populations. It may originate from any part of the sympathetic nervous system, but it most commonly arises from the paraspinal sympathetic ganglia in the abdomen or mediastinum. Local lymphadenopathy and distant metastasis to the central nervous system, orbit, and liver might be detected; however, it rarely includes soft tissue or musculoskeletal involvement. Case Report. Here, we report a 10-month-old infant presented with a right thigh mass with an otherwise benign physical exam and medical history. MRI of the lower extremities suggested tumoral infiltration in the soft tissue of both thighs, predominantly on the right side. Surgical pathology of the lesion confirmed neuroblastoma. A large subhepatic mass and paraaortic lymphadenopathy in the abdominal CT scan and metaiodobenzylguanidine scan findings favored primary abdominal neuroblastoma that had spread to lower extremities. The patient has been in remission since the completion of chemotherapy. Conclusion. Neuroblastoma should be considered in infants with an abnormal mass in extremities. Due to its aggressive nature, most patients struggle with distant and local tumor spread at diagnosis. Therefore, any abnormal signs and symptoms, especially in younger pediatrics, warrant immediate evaluation to avoid tumor expansion. |
| format | Article |
| id | doaj-art-2b913dec599947bf99d0960a4ff268b2 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-2b913dec599947bf99d0960a4ff268b22025-02-03T01:27:23ZengWileyCase Reports in Medicine1687-96271687-96352021-01-01202110.1155/2021/32263193226319Neuroblastoma Soft Tissue Metastasis in a 10-Month-Old Infant with a Right Thigh MassShokouh Taghipour Zahir0Fateme Salemi1Department of Pathology, Shahid Sadoughi General Hospital, Yazd, IranIslamic Azad University of Medical Sciences, School of Medicine, Yazd, IranBackground. Neuroblastoma is a solid tumor that occurs more frequently in pediatric populations. It may originate from any part of the sympathetic nervous system, but it most commonly arises from the paraspinal sympathetic ganglia in the abdomen or mediastinum. Local lymphadenopathy and distant metastasis to the central nervous system, orbit, and liver might be detected; however, it rarely includes soft tissue or musculoskeletal involvement. Case Report. Here, we report a 10-month-old infant presented with a right thigh mass with an otherwise benign physical exam and medical history. MRI of the lower extremities suggested tumoral infiltration in the soft tissue of both thighs, predominantly on the right side. Surgical pathology of the lesion confirmed neuroblastoma. A large subhepatic mass and paraaortic lymphadenopathy in the abdominal CT scan and metaiodobenzylguanidine scan findings favored primary abdominal neuroblastoma that had spread to lower extremities. The patient has been in remission since the completion of chemotherapy. Conclusion. Neuroblastoma should be considered in infants with an abnormal mass in extremities. Due to its aggressive nature, most patients struggle with distant and local tumor spread at diagnosis. Therefore, any abnormal signs and symptoms, especially in younger pediatrics, warrant immediate evaluation to avoid tumor expansion.http://dx.doi.org/10.1155/2021/3226319 |
| spellingShingle | Shokouh Taghipour Zahir Fateme Salemi Neuroblastoma Soft Tissue Metastasis in a 10-Month-Old Infant with a Right Thigh Mass Case Reports in Medicine |
| title | Neuroblastoma Soft Tissue Metastasis in a 10-Month-Old Infant with a Right Thigh Mass |
| title_full | Neuroblastoma Soft Tissue Metastasis in a 10-Month-Old Infant with a Right Thigh Mass |
| title_fullStr | Neuroblastoma Soft Tissue Metastasis in a 10-Month-Old Infant with a Right Thigh Mass |
| title_full_unstemmed | Neuroblastoma Soft Tissue Metastasis in a 10-Month-Old Infant with a Right Thigh Mass |
| title_short | Neuroblastoma Soft Tissue Metastasis in a 10-Month-Old Infant with a Right Thigh Mass |
| title_sort | neuroblastoma soft tissue metastasis in a 10 month old infant with a right thigh mass |
| url | http://dx.doi.org/10.1155/2021/3226319 |
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