Q Fever: Current State of Knowledge and Perspectives of Research of a Neglected Zoonosis
Q fever is an ubiquitous zoonosis caused by an resistant intracellular bacterium, Coxiella burnetii. In certain areas, Q fever can be a severe public health problem, and awareness of the disease must be promoted worldwide. Nevertheless, knowledge of Coxiella burnetii remains limited to this day. Its...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2011/248418 |
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| _version_ | 1832551867152859136 |
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| author | Sarah Rebecca Porter Guy Czaplicki Jacques Mainil Raphaël Guattéo Claude Saegerman |
| author_facet | Sarah Rebecca Porter Guy Czaplicki Jacques Mainil Raphaël Guattéo Claude Saegerman |
| author_sort | Sarah Rebecca Porter |
| collection | DOAJ |
| description | Q fever is an ubiquitous zoonosis caused by an resistant intracellular bacterium, Coxiella burnetii. In certain areas, Q fever can be a severe public health problem, and awareness of the disease must be promoted worldwide. Nevertheless, knowledge of Coxiella burnetii remains limited to this day. Its resistant (intracellular and environmental) and infectious properties have been poorly investigated. Further understanding of the interactions between the infected host and the bacteria is necessary. Domestic ruminants are considered as the main reservoir of bacteria. Infected animals shed highly infectious organisms in milk, feces, urine, vaginal mucus, and, very importantly, birth products. Inhalation is the main route of infection. Frequently asymptomatic in humans and animals, Q fever can cause acute or chronic infections. Financial consequences of infection can be dramatic at herd level. Vaccination with inactive whole-cell bacteria has been performed and proved effective in humans and animals. However, inactive whole-cell vaccines present several defects. Recombinant vaccines have been developed in experimental conditions and have great potential for the future. Q fever is a challenging disease for scientists as significant further investigations are necessary. Great research opportunities are available to reach a better understanding and thus a better prevention and control of the infection. |
| format | Article |
| id | doaj-art-2b6320c426f545029b0f5f0c61439001 |
| institution | Kabale University |
| issn | 1687-918X 1687-9198 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Microbiology |
| spelling | doaj-art-2b6320c426f545029b0f5f0c614390012025-02-03T06:00:14ZengWileyInternational Journal of Microbiology1687-918X1687-91982011-01-01201110.1155/2011/248418248418Q Fever: Current State of Knowledge and Perspectives of Research of a Neglected ZoonosisSarah Rebecca Porter0Guy Czaplicki1Jacques Mainil2Raphaël Guattéo3Claude Saegerman4Research Unit in Epidemiology and Risk Analysis Applied to Veterinary Sciences (UREAR), Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine, University of Liège, B42, Boulevard de Colonster 20, 4000 Liège, BelgiumDépartement de Sérologie, Association Régionale de Santé et d'Identification Animales, 4431 Loncin, BelgiumLaboratory of Bacteriology, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine, University of Liège, Sart-Tilman B43a, 4000 Liège, BelgiumUMR 1300 Bio-Agression, Epidémiologie et Analyse de Risque, INRA, 44307 Nantes, FranceResearch Unit in Epidemiology and Risk Analysis Applied to Veterinary Sciences (UREAR), Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine, University of Liège, B42, Boulevard de Colonster 20, 4000 Liège, BelgiumQ fever is an ubiquitous zoonosis caused by an resistant intracellular bacterium, Coxiella burnetii. In certain areas, Q fever can be a severe public health problem, and awareness of the disease must be promoted worldwide. Nevertheless, knowledge of Coxiella burnetii remains limited to this day. Its resistant (intracellular and environmental) and infectious properties have been poorly investigated. Further understanding of the interactions between the infected host and the bacteria is necessary. Domestic ruminants are considered as the main reservoir of bacteria. Infected animals shed highly infectious organisms in milk, feces, urine, vaginal mucus, and, very importantly, birth products. Inhalation is the main route of infection. Frequently asymptomatic in humans and animals, Q fever can cause acute or chronic infections. Financial consequences of infection can be dramatic at herd level. Vaccination with inactive whole-cell bacteria has been performed and proved effective in humans and animals. However, inactive whole-cell vaccines present several defects. Recombinant vaccines have been developed in experimental conditions and have great potential for the future. Q fever is a challenging disease for scientists as significant further investigations are necessary. Great research opportunities are available to reach a better understanding and thus a better prevention and control of the infection.http://dx.doi.org/10.1155/2011/248418 |
| spellingShingle | Sarah Rebecca Porter Guy Czaplicki Jacques Mainil Raphaël Guattéo Claude Saegerman Q Fever: Current State of Knowledge and Perspectives of Research of a Neglected Zoonosis International Journal of Microbiology |
| title | Q Fever: Current State of Knowledge and Perspectives of Research of a Neglected Zoonosis |
| title_full | Q Fever: Current State of Knowledge and Perspectives of Research of a Neglected Zoonosis |
| title_fullStr | Q Fever: Current State of Knowledge and Perspectives of Research of a Neglected Zoonosis |
| title_full_unstemmed | Q Fever: Current State of Knowledge and Perspectives of Research of a Neglected Zoonosis |
| title_short | Q Fever: Current State of Knowledge and Perspectives of Research of a Neglected Zoonosis |
| title_sort | q fever current state of knowledge and perspectives of research of a neglected zoonosis |
| url | http://dx.doi.org/10.1155/2011/248418 |
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