Engineered sequestrins inhibit aggregation of pathogenic alpha-synuclein mutants

Engineered sequestrins inhibit aggregation of pathogenic alpha-synuclein mutants

Misfolding and aggregation of the neuronal protein alpha-synuclein (aSyn) has been identified as a hallmark of Parkinson’s disease (PD) pathology and other synucleinopathies. Preventing formation of intracellular aSyn accumulations constitutes a therapeutic strategy against disease development. We r...

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Bibliographic Details
Main Authors: Linnea Charlotta Hjelm, Wojciech Paslawski, Christofer Lendel, Siri Flemming Svedmark, Per Svenningsson, Stefan Ståhl, Hanna Lindberg, John Löfblom
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
affibody molecule
alpha-synuclein
directed evolution
Parkinson’s disease
phage display
sequestrin
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1574755/full
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