Polymorphisms of Tumor Necrosis Factor Alpha in Moroccan Patients with Gastric Pathology: New Single-Nucleotide Polymorphisms in TNF-α−193 (G/A)
Polymorphisms in tumor necrosis factor alpha (TNF-α) gene are emerging as key determinants of gastric diseases. The TNF-α−308 (G/A) and TNF-α−238 (G/A) single-nucleotide polymorphisms SNPs are the most extensively studied. However, all these studies are conducted in Caucasian and Asian populations....
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/143941 |
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| author | A. Essadik H. Jouhadi T. Rhouda S. Nadifiyine A. Kettani F. Maachi |
| author_facet | A. Essadik H. Jouhadi T. Rhouda S. Nadifiyine A. Kettani F. Maachi |
| author_sort | A. Essadik |
| collection | DOAJ |
| description | Polymorphisms in tumor necrosis factor alpha (TNF-α) gene are emerging as key determinants of gastric diseases. The TNF-α−308 (G/A) and TNF-α−238 (G/A) single-nucleotide polymorphisms SNPs are the most extensively studied. However, all these studies are conducted in Caucasian and Asian populations. Thus, for the first time in Africa, we sought to investigate whether polymorphisms in TNF-α gene were associated with the development of gastric pathology in Morocco. Two SNPs located in the promoter region (positions −308 and −238) in TNF-α gene were genotyped in 244 individuals (170 patients and 74 healthy controls). Odds ratios (ORs) and 95% confidence intervals (CI) were estimated using logistic regression analysis. The TNF-α−238 (G/A) genotype was significantly associated with a high risk of gastritis and gastric cancer (GC) (P=0.001 and P=0.002, resp.). Furthermore, a new polymorphism located in the promoter region at position −193 in TNF-α gene was identified. The distribution of this SNP was markedly different in patients suffering from ulcers. The association between TNF-α−193 (G/A) genotype and high risk of ulcer was significant (P=0.03). These results suggest that the TNF-α−193 (G/A) allele has a protective function against gastric cancer by developing ulcer. |
| format | Article |
| id | doaj-art-2b5db2100867429ea1cab6bf9d11438f |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-2b5db2100867429ea1cab6bf9d11438f2025-02-03T05:54:17ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/143941143941Polymorphisms of Tumor Necrosis Factor Alpha in Moroccan Patients with Gastric Pathology: New Single-Nucleotide Polymorphisms in TNF-α−193 (G/A)A. Essadik0H. Jouhadi1T. Rhouda2S. Nadifiyine3A. Kettani4F. Maachi5Laboratory of Pathology-Digestif-Oncology, Pasteur Institute of Morocco, 20360 Casablanca, MoroccoDepartment of Radiotherapy Oncology, Ibn Rochd University Hospital, 20000 Casablanca, MoroccoLaboratory of Molecular Genetics and Pathophysiology, Faculty of Sciences Ben M’sik, University Hassan II, 7955 Casablanca, MoroccoLaboratory of Pathology-Digestif-Oncology, Pasteur Institute of Morocco, 20360 Casablanca, MoroccoLaboratory of Biology and Health, Molecular Modeling and Quality Control Team, Faculty of Sciences Ben M’sik, University Hassan II, 7955 Casablanca, MoroccoLaboratory of Pathology-Digestif-Oncology, Pasteur Institute of Morocco, 20360 Casablanca, MoroccoPolymorphisms in tumor necrosis factor alpha (TNF-α) gene are emerging as key determinants of gastric diseases. The TNF-α−308 (G/A) and TNF-α−238 (G/A) single-nucleotide polymorphisms SNPs are the most extensively studied. However, all these studies are conducted in Caucasian and Asian populations. Thus, for the first time in Africa, we sought to investigate whether polymorphisms in TNF-α gene were associated with the development of gastric pathology in Morocco. Two SNPs located in the promoter region (positions −308 and −238) in TNF-α gene were genotyped in 244 individuals (170 patients and 74 healthy controls). Odds ratios (ORs) and 95% confidence intervals (CI) were estimated using logistic regression analysis. The TNF-α−238 (G/A) genotype was significantly associated with a high risk of gastritis and gastric cancer (GC) (P=0.001 and P=0.002, resp.). Furthermore, a new polymorphism located in the promoter region at position −193 in TNF-α gene was identified. The distribution of this SNP was markedly different in patients suffering from ulcers. The association between TNF-α−193 (G/A) genotype and high risk of ulcer was significant (P=0.03). These results suggest that the TNF-α−193 (G/A) allele has a protective function against gastric cancer by developing ulcer.http://dx.doi.org/10.1155/2015/143941 |
| spellingShingle | A. Essadik H. Jouhadi T. Rhouda S. Nadifiyine A. Kettani F. Maachi Polymorphisms of Tumor Necrosis Factor Alpha in Moroccan Patients with Gastric Pathology: New Single-Nucleotide Polymorphisms in TNF-α−193 (G/A) Mediators of Inflammation |
| title | Polymorphisms of Tumor Necrosis Factor Alpha in Moroccan Patients with Gastric Pathology: New Single-Nucleotide Polymorphisms in TNF-α−193 (G/A) |
| title_full | Polymorphisms of Tumor Necrosis Factor Alpha in Moroccan Patients with Gastric Pathology: New Single-Nucleotide Polymorphisms in TNF-α−193 (G/A) |
| title_fullStr | Polymorphisms of Tumor Necrosis Factor Alpha in Moroccan Patients with Gastric Pathology: New Single-Nucleotide Polymorphisms in TNF-α−193 (G/A) |
| title_full_unstemmed | Polymorphisms of Tumor Necrosis Factor Alpha in Moroccan Patients with Gastric Pathology: New Single-Nucleotide Polymorphisms in TNF-α−193 (G/A) |
| title_short | Polymorphisms of Tumor Necrosis Factor Alpha in Moroccan Patients with Gastric Pathology: New Single-Nucleotide Polymorphisms in TNF-α−193 (G/A) |
| title_sort | polymorphisms of tumor necrosis factor alpha in moroccan patients with gastric pathology new single nucleotide polymorphisms in tnf α 193 g a |
| url | http://dx.doi.org/10.1155/2015/143941 |
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