Early Magnetic Resonance Detection of Natalizumab-Related Progressive Multifocal Leukoencephalopathy in a Patient with Multiple Sclerosis
Diagnosis of progressive multifocal leukoencephalopathy is usually based on the clinical presentation, on the demonstration of the brain lesions at the magnetic resonance imaging examination, and on the detection of the JC virus DNA in the cerebrospinal fluid with high sensitive polymerase chain rea...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Radiology |
| Online Access: | http://dx.doi.org/10.1155/2013/415873 |
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| author | Guglielmo Manenti Simone Altobelli Marco Nezzo Marco Antonicoli Erald Vasili Luca Neroni Roberto Floris Giovanni Simonetti |
| author_facet | Guglielmo Manenti Simone Altobelli Marco Nezzo Marco Antonicoli Erald Vasili Luca Neroni Roberto Floris Giovanni Simonetti |
| author_sort | Guglielmo Manenti |
| collection | DOAJ |
| description | Diagnosis of progressive multifocal leukoencephalopathy is usually based on the clinical presentation, on the demonstration of the brain lesions at the magnetic resonance imaging examination, and on the detection of the JC virus DNA in the cerebrospinal fluid with high sensitive polymerase chain reaction. The role of magnetic resonance imaging specifically in natalizumab-associated progressive multifocal leukoencephalopathy is strengthening, and it is gaining importance not only as an irreplaceable diagnostic tool but also as a surveillance and risk stratifying tool in treated patients. While other imaging techniques such as computed tomography lack sensitivity and specificity, magnetic resonance performed with morphological and functional sequences offers clinicians the possibility to early identify the stage of the disease and the emergence of an immune reconstitution inflammatory syndrome after natalizumab blood removal plasmapheresis. |
| format | Article |
| id | doaj-art-2b57be31895248b28c0ef0de67912e51 |
| institution | Kabale University |
| issn | 2090-6862 2090-6870 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Radiology |
| spelling | doaj-art-2b57be31895248b28c0ef0de67912e512025-02-03T01:21:50ZengWileyCase Reports in Radiology2090-68622090-68702013-01-01201310.1155/2013/415873415873Early Magnetic Resonance Detection of Natalizumab-Related Progressive Multifocal Leukoencephalopathy in a Patient with Multiple SclerosisGuglielmo Manenti0Simone Altobelli1Marco Nezzo2Marco Antonicoli3Erald Vasili4Luca Neroni5Roberto Floris6Giovanni Simonetti7Department of Diagnostic and Molecular Imaging, Interventional Radiology and Radiation Therapy, Fondazione Policlinico “Tor Vergata”, Viale Oxford 81, 00133 Rome, ItalyDepartment of Diagnostic and Molecular Imaging, Interventional Radiology and Radiation Therapy, Fondazione Policlinico “Tor Vergata”, Viale Oxford 81, 00133 Rome, ItalyDepartment of Diagnostic and Molecular Imaging, Interventional Radiology and Radiation Therapy, Fondazione Policlinico “Tor Vergata”, Viale Oxford 81, 00133 Rome, ItalyDepartment of Diagnostic and Molecular Imaging, Interventional Radiology and Radiation Therapy, Fondazione Policlinico “Tor Vergata”, Viale Oxford 81, 00133 Rome, ItalyDepartment of Diagnostic and Molecular Imaging, Interventional Radiology and Radiation Therapy, Fondazione Policlinico “Tor Vergata”, Viale Oxford 81, 00133 Rome, ItalyDepartment of Diagnostic and Molecular Imaging, Interventional Radiology and Radiation Therapy, Fondazione Policlinico “Tor Vergata”, Viale Oxford 81, 00133 Rome, ItalyDepartment of Diagnostic and Molecular Imaging, Interventional Radiology and Radiation Therapy, Fondazione Policlinico “Tor Vergata”, Viale Oxford 81, 00133 Rome, ItalyDepartment of Diagnostic and Molecular Imaging, Interventional Radiology and Radiation Therapy, Fondazione Policlinico “Tor Vergata”, Viale Oxford 81, 00133 Rome, ItalyDiagnosis of progressive multifocal leukoencephalopathy is usually based on the clinical presentation, on the demonstration of the brain lesions at the magnetic resonance imaging examination, and on the detection of the JC virus DNA in the cerebrospinal fluid with high sensitive polymerase chain reaction. The role of magnetic resonance imaging specifically in natalizumab-associated progressive multifocal leukoencephalopathy is strengthening, and it is gaining importance not only as an irreplaceable diagnostic tool but also as a surveillance and risk stratifying tool in treated patients. While other imaging techniques such as computed tomography lack sensitivity and specificity, magnetic resonance performed with morphological and functional sequences offers clinicians the possibility to early identify the stage of the disease and the emergence of an immune reconstitution inflammatory syndrome after natalizumab blood removal plasmapheresis.http://dx.doi.org/10.1155/2013/415873 |
| spellingShingle | Guglielmo Manenti Simone Altobelli Marco Nezzo Marco Antonicoli Erald Vasili Luca Neroni Roberto Floris Giovanni Simonetti Early Magnetic Resonance Detection of Natalizumab-Related Progressive Multifocal Leukoencephalopathy in a Patient with Multiple Sclerosis Case Reports in Radiology |
| title | Early Magnetic Resonance Detection of Natalizumab-Related Progressive Multifocal Leukoencephalopathy in a Patient with Multiple Sclerosis |
| title_full | Early Magnetic Resonance Detection of Natalizumab-Related Progressive Multifocal Leukoencephalopathy in a Patient with Multiple Sclerosis |
| title_fullStr | Early Magnetic Resonance Detection of Natalizumab-Related Progressive Multifocal Leukoencephalopathy in a Patient with Multiple Sclerosis |
| title_full_unstemmed | Early Magnetic Resonance Detection of Natalizumab-Related Progressive Multifocal Leukoencephalopathy in a Patient with Multiple Sclerosis |
| title_short | Early Magnetic Resonance Detection of Natalizumab-Related Progressive Multifocal Leukoencephalopathy in a Patient with Multiple Sclerosis |
| title_sort | early magnetic resonance detection of natalizumab related progressive multifocal leukoencephalopathy in a patient with multiple sclerosis |
| url | http://dx.doi.org/10.1155/2013/415873 |
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