A Case of Childhood Severe Paroxysmal Cold Hemoglobinuria with Acute Renal Failure Successfully Treated with Plasma Exchange and Eculizumab
We describe the case of a 4-year-old female who presented with sepsis and disseminated intravascular coagulation (DIC), developed ongoing intravascular hemolysis with acute renal failure from suspected pigment-induced acute tubular necrosis necessitating continuous renal replacement therapy (CRRT) f...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2022/3267189 |
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| _version_ | 1832562389670690816 |
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| author | Jessica Pelletier Chad Ward Matthew Borloz Anne Ickes Susan Guelich Erwood Edwards |
| author_facet | Jessica Pelletier Chad Ward Matthew Borloz Anne Ickes Susan Guelich Erwood Edwards |
| author_sort | Jessica Pelletier |
| collection | DOAJ |
| description | We describe the case of a 4-year-old female who presented with sepsis and disseminated intravascular coagulation (DIC), developed ongoing intravascular hemolysis with acute renal failure from suspected pigment-induced acute tubular necrosis necessitating continuous renal replacement therapy (CRRT) for five days followed by four episodes of intermittent hemodialysis (iHD), and was subsequently diagnosed with paroxysmal cold hemoglobinuria (PCH). She was successfully treated with plasma exchange and eculizumab, a humanized monoclonal antibody targeting complement protein C5, and demonstrated significant improvement of hemolysis and recovery of renal function. |
| format | Article |
| id | doaj-art-2b4b6a57eaaa4cbaa11467e2e625a4a0 |
| institution | Kabale University |
| issn | 2090-6811 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-2b4b6a57eaaa4cbaa11467e2e625a4a02025-02-03T01:22:45ZengWileyCase Reports in Pediatrics2090-68112022-01-01202210.1155/2022/3267189A Case of Childhood Severe Paroxysmal Cold Hemoglobinuria with Acute Renal Failure Successfully Treated with Plasma Exchange and EculizumabJessica Pelletier0Chad Ward1Matthew Borloz2Anne Ickes3Susan Guelich4Erwood Edwards5Department of Emergency MedicineDepartment of Pediatric Intensive Care MedicineDepartment of Emergency MedicineDepartment of Emergency MedicinePediatric NephrologyCarilion Children's Pediatric Hematology/OncologyWe describe the case of a 4-year-old female who presented with sepsis and disseminated intravascular coagulation (DIC), developed ongoing intravascular hemolysis with acute renal failure from suspected pigment-induced acute tubular necrosis necessitating continuous renal replacement therapy (CRRT) for five days followed by four episodes of intermittent hemodialysis (iHD), and was subsequently diagnosed with paroxysmal cold hemoglobinuria (PCH). She was successfully treated with plasma exchange and eculizumab, a humanized monoclonal antibody targeting complement protein C5, and demonstrated significant improvement of hemolysis and recovery of renal function.http://dx.doi.org/10.1155/2022/3267189 |
| spellingShingle | Jessica Pelletier Chad Ward Matthew Borloz Anne Ickes Susan Guelich Erwood Edwards A Case of Childhood Severe Paroxysmal Cold Hemoglobinuria with Acute Renal Failure Successfully Treated with Plasma Exchange and Eculizumab Case Reports in Pediatrics |
| title | A Case of Childhood Severe Paroxysmal Cold Hemoglobinuria with Acute Renal Failure Successfully Treated with Plasma Exchange and Eculizumab |
| title_full | A Case of Childhood Severe Paroxysmal Cold Hemoglobinuria with Acute Renal Failure Successfully Treated with Plasma Exchange and Eculizumab |
| title_fullStr | A Case of Childhood Severe Paroxysmal Cold Hemoglobinuria with Acute Renal Failure Successfully Treated with Plasma Exchange and Eculizumab |
| title_full_unstemmed | A Case of Childhood Severe Paroxysmal Cold Hemoglobinuria with Acute Renal Failure Successfully Treated with Plasma Exchange and Eculizumab |
| title_short | A Case of Childhood Severe Paroxysmal Cold Hemoglobinuria with Acute Renal Failure Successfully Treated with Plasma Exchange and Eculizumab |
| title_sort | case of childhood severe paroxysmal cold hemoglobinuria with acute renal failure successfully treated with plasma exchange and eculizumab |
| url | http://dx.doi.org/10.1155/2022/3267189 |
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