The Pathology of Orthopedic Implant Failure Is Mediated by Innate Immune System Cytokines

All of the over 1 million total joint replacements implanted in the US each year are expected to eventually fail after 15–25 years of use, due to slow progressive subtle inflammation at the bone implant interface. This inflammatory disease state is caused by implant debris acting, primarily, on inna...

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Bibliographic Details
Main Authors: Stefan Landgraeber, Marcus Jäger, Joshua J. Jacobs, Nadim James Hallab
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2014/185150
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