Synthesis of Benzofuro[3,2-e]-1,4-diazepines of Pharmacological Interest
The title compounds (4a,b) were prepared by chloroacetylation of 2-acyl-3-aminobenzofuran(1a,b) and subsequent treatment with hexamethylene tetramine in ethanol via the complex salts (3a,b). Similar reaction with ethyl 3-aminobenzofuran-2 carboxylate (5) produced 3H-benzofuro[3,2-e]-1,4-diazepin2,5(...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2008/920926 |
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| author | K. M. Basavaraja V. P. Vaidya C. Chandrashekhar |
| author_facet | K. M. Basavaraja V. P. Vaidya C. Chandrashekhar |
| author_sort | K. M. Basavaraja |
| collection | DOAJ |
| description | The title compounds (4a,b) were prepared by chloroacetylation of 2-acyl-3-aminobenzofuran(1a,b) and subsequent treatment with hexamethylene tetramine in ethanol via the complex salts (3a,b). Similar reaction with ethyl 3-aminobenzofuran-2 carboxylate (5) produced 3H-benzofuro[3,2-e]-1,4-diazepin2,5(1H,4H)-dione (7) in good yield. All the newly synthesized compounds are characterized by elemental analysis and spectral studies, and evaluated for antimicrobial and anticonvulsant activities. |
| format | Article |
| id | doaj-art-2b40f5c00d894f07b67132f1329dd610 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-2b40f5c00d894f07b67132f1329dd6102025-02-03T06:11:22ZengWileyE-Journal of Chemistry0973-49452090-98102008-01-015356757110.1155/2008/920926Synthesis of Benzofuro[3,2-e]-1,4-diazepines of Pharmacological InterestK. M. Basavaraja0V. P. Vaidya1C. Chandrashekhar2Department of Industrial Chemistry, Gulberga University, Jnana Ganga, Bellary-Dist: Bellary, Karnataka, IndiaDepartment of Chemistry, Kuvempu University, Jnana Sahyadri, Shankaraghatta-577451 Dist: Shimoga, Karnataka, IndiaDepartment of Chemistry, Kuvempu University, Jnana Sahyadri, Shankaraghatta-577451 Dist: Shimoga, Karnataka, IndiaThe title compounds (4a,b) were prepared by chloroacetylation of 2-acyl-3-aminobenzofuran(1a,b) and subsequent treatment with hexamethylene tetramine in ethanol via the complex salts (3a,b). Similar reaction with ethyl 3-aminobenzofuran-2 carboxylate (5) produced 3H-benzofuro[3,2-e]-1,4-diazepin2,5(1H,4H)-dione (7) in good yield. All the newly synthesized compounds are characterized by elemental analysis and spectral studies, and evaluated for antimicrobial and anticonvulsant activities.http://dx.doi.org/10.1155/2008/920926 |
| spellingShingle | K. M. Basavaraja V. P. Vaidya C. Chandrashekhar Synthesis of Benzofuro[3,2-e]-1,4-diazepines of Pharmacological Interest E-Journal of Chemistry |
| title | Synthesis of Benzofuro[3,2-e]-1,4-diazepines of Pharmacological Interest |
| title_full | Synthesis of Benzofuro[3,2-e]-1,4-diazepines of Pharmacological Interest |
| title_fullStr | Synthesis of Benzofuro[3,2-e]-1,4-diazepines of Pharmacological Interest |
| title_full_unstemmed | Synthesis of Benzofuro[3,2-e]-1,4-diazepines of Pharmacological Interest |
| title_short | Synthesis of Benzofuro[3,2-e]-1,4-diazepines of Pharmacological Interest |
| title_sort | synthesis of benzofuro 3 2 e 1 4 diazepines of pharmacological interest |
| url | http://dx.doi.org/10.1155/2008/920926 |
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