Synthesis and Biological Evaluation of New (−)-Gossypol-Derived Schiff Bases and Hydrazones
A series of 14 new (-)-gossypol Schiff bases and hydrazones have been synthesized via an in situ procedure in high yields. Structural data showed that all target compounds exist as the enamine tautomer. Bioassays showed that several compounds exhibited cytotoxic effects against three human cancer ce...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2017/3687182 |
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| author | Vu Van Vu Trinh Thi Nhung Nguyen Thi Thanh Luu Van Chinh Vu Dinh Tien Vu Thu Thuy Do Thi Thao Nguyen Hai Nam Angela Koeckritz Tran Khac Vu |
| author_facet | Vu Van Vu Trinh Thi Nhung Nguyen Thi Thanh Luu Van Chinh Vu Dinh Tien Vu Thu Thuy Do Thi Thao Nguyen Hai Nam Angela Koeckritz Tran Khac Vu |
| author_sort | Vu Van Vu |
| collection | DOAJ |
| description | A series of 14 new (-)-gossypol Schiff bases and hydrazones have been synthesized via an in situ procedure in high yields. Structural data showed that all target compounds exist as the enamine tautomer. Bioassays showed that several compounds exhibited cytotoxic effects against three human cancer cell lines. Compound 8a showed the greatest cytotoxic effect against hepatocellular carcinoma (HepG2), lung carcinoma (LU-1), and breast cancer (MCF-7) cell lines with IC50 values of 20.93, 13.58, and 9.40 μM, respectively. However, in an antibacterial test, compounds 8a and 8b inhibited Staphylococcus aureus and Bacillus cereus and compound 8e inhibited only Staphylococcus aureus at the same MIC values of 1024 μg/ml. |
| format | Article |
| id | doaj-art-2b39cd247f874222b32549bcc59600c9 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-2b39cd247f874222b32549bcc59600c92025-02-03T05:46:47ZengWileyJournal of Chemistry2090-90632090-90712017-01-01201710.1155/2017/36871823687182Synthesis and Biological Evaluation of New (−)-Gossypol-Derived Schiff Bases and HydrazonesVu Van Vu0Trinh Thi Nhung1Nguyen Thi Thanh2Luu Van Chinh3Vu Dinh Tien4Vu Thu Thuy5Do Thi Thao6Nguyen Hai Nam7Angela Koeckritz8Tran Khac Vu9School of Chemical Engineering, Hanoi University of Science and Technology, No. 1 Dai Co Viet, Hai Ba Trung, Hanoi, VietnamSchool of Chemical Engineering, Hanoi University of Science and Technology, No. 1 Dai Co Viet, Hai Ba Trung, Hanoi, VietnamSchool of Chemical Engineering, Hanoi University of Science and Technology, No. 1 Dai Co Viet, Hai Ba Trung, Hanoi, VietnamInstitute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, VietnamSchool of Chemical Engineering, Hanoi University of Science and Technology, No. 1 Dai Co Viet, Hai Ba Trung, Hanoi, VietnamSchool of Chemical Engineering, Hanoi University of Science and Technology, No. 1 Dai Co Viet, Hai Ba Trung, Hanoi, VietnamInstitute of Biotechnology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, VietnamHanoi University of Pharmacy (HUP), 13-15 Le Thanh Tong, Hanoi, VietnamLeibniz Institute for Catalysis at the University of Rostock, Albert-Einstein-Str. 29A, 18059 Rostock, GermanySchool of Chemical Engineering, Hanoi University of Science and Technology, No. 1 Dai Co Viet, Hai Ba Trung, Hanoi, VietnamA series of 14 new (-)-gossypol Schiff bases and hydrazones have been synthesized via an in situ procedure in high yields. Structural data showed that all target compounds exist as the enamine tautomer. Bioassays showed that several compounds exhibited cytotoxic effects against three human cancer cell lines. Compound 8a showed the greatest cytotoxic effect against hepatocellular carcinoma (HepG2), lung carcinoma (LU-1), and breast cancer (MCF-7) cell lines with IC50 values of 20.93, 13.58, and 9.40 μM, respectively. However, in an antibacterial test, compounds 8a and 8b inhibited Staphylococcus aureus and Bacillus cereus and compound 8e inhibited only Staphylococcus aureus at the same MIC values of 1024 μg/ml.http://dx.doi.org/10.1155/2017/3687182 |
| spellingShingle | Vu Van Vu Trinh Thi Nhung Nguyen Thi Thanh Luu Van Chinh Vu Dinh Tien Vu Thu Thuy Do Thi Thao Nguyen Hai Nam Angela Koeckritz Tran Khac Vu Synthesis and Biological Evaluation of New (−)-Gossypol-Derived Schiff Bases and Hydrazones Journal of Chemistry |
| title | Synthesis and Biological Evaluation of New (−)-Gossypol-Derived Schiff Bases and Hydrazones |
| title_full | Synthesis and Biological Evaluation of New (−)-Gossypol-Derived Schiff Bases and Hydrazones |
| title_fullStr | Synthesis and Biological Evaluation of New (−)-Gossypol-Derived Schiff Bases and Hydrazones |
| title_full_unstemmed | Synthesis and Biological Evaluation of New (−)-Gossypol-Derived Schiff Bases and Hydrazones |
| title_short | Synthesis and Biological Evaluation of New (−)-Gossypol-Derived Schiff Bases and Hydrazones |
| title_sort | synthesis and biological evaluation of new gossypol derived schiff bases and hydrazones |
| url | http://dx.doi.org/10.1155/2017/3687182 |
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