The Role of T Helper (TH)17 Cells as a Double-Edged Sword in the Interplay of Infection and Autoimmunity with a Focus on Xenobiotic-Induced Immunomodulation
Extensive research in recent years suggests that exposure to xenobiotic stimuli plays a critical role in autoimmunity induction and severity and that the resulting response would be exacerbated in individuals with an infection-aroused immune system. In this context, heavy metals constitute a promine...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/374769 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832567637777842176 |
|---|---|
| author | Nasr Y. A. Hemdan Ahmed M. Abu El-Saad Ulrich Sack |
| author_facet | Nasr Y. A. Hemdan Ahmed M. Abu El-Saad Ulrich Sack |
| author_sort | Nasr Y. A. Hemdan |
| collection | DOAJ |
| description | Extensive research in recent years suggests that exposure to xenobiotic stimuli plays a critical role in autoimmunity induction and severity and that the resulting response would be exacerbated in individuals with an infection-aroused immune system. In this context, heavy metals constitute a prominent category of xenobiotic substances, known to alter divergent immune cell responses in accidentally and occupationally exposed individuals, thereby increasing the susceptibility to autoimmunity and cancer, especially when accompanied by inflammation-triggered persistent sensitization. This perception is learned from experimental models of infection and epidemiologic studies and clearly underscores the interplay of exposure to such immunomodulatory elements with pre- or postexposure infectious events. Further, the TH17 cell subset, known to be associated with a growing list of autoimmune manifestations, may be the “superstar” at the interface of xenobiotic exposure and autoimmunity. In this review, the most recently established links to this nomination are short-listed to create a framework to better understand new insights into TH17’s contributions to autoimmunity. |
| format | Article |
| id | doaj-art-2b34bf14a01d4fc4860421309ad6fad0 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-2b34bf14a01d4fc4860421309ad6fad02025-02-03T01:00:53ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/374769374769The Role of T Helper (TH)17 Cells as a Double-Edged Sword in the Interplay of Infection and Autoimmunity with a Focus on Xenobiotic-Induced ImmunomodulationNasr Y. A. Hemdan0Ahmed M. Abu El-Saad1Ulrich Sack2Department of Anesthesiology and Intensive Care Medicine, SG Sepsis Research, Center for Sepsis Control and Care, Jena University Hospital, 07740 Jena, GermanyDepartment of Zoology, Faculty of Science, University of Alexandria, Moharram Bey, Alexandria 21511, EgyptInstitute of Clinical Immunology, Medical Faculty, University of Leipzig, Johannisallee 30, 04103 Leipzig, GermanyExtensive research in recent years suggests that exposure to xenobiotic stimuli plays a critical role in autoimmunity induction and severity and that the resulting response would be exacerbated in individuals with an infection-aroused immune system. In this context, heavy metals constitute a prominent category of xenobiotic substances, known to alter divergent immune cell responses in accidentally and occupationally exposed individuals, thereby increasing the susceptibility to autoimmunity and cancer, especially when accompanied by inflammation-triggered persistent sensitization. This perception is learned from experimental models of infection and epidemiologic studies and clearly underscores the interplay of exposure to such immunomodulatory elements with pre- or postexposure infectious events. Further, the TH17 cell subset, known to be associated with a growing list of autoimmune manifestations, may be the “superstar” at the interface of xenobiotic exposure and autoimmunity. In this review, the most recently established links to this nomination are short-listed to create a framework to better understand new insights into TH17’s contributions to autoimmunity.http://dx.doi.org/10.1155/2013/374769 |
| spellingShingle | Nasr Y. A. Hemdan Ahmed M. Abu El-Saad Ulrich Sack The Role of T Helper (TH)17 Cells as a Double-Edged Sword in the Interplay of Infection and Autoimmunity with a Focus on Xenobiotic-Induced Immunomodulation Clinical and Developmental Immunology |
| title | The Role of T Helper (TH)17 Cells as a Double-Edged Sword in the Interplay of Infection and Autoimmunity with a Focus on Xenobiotic-Induced Immunomodulation |
| title_full | The Role of T Helper (TH)17 Cells as a Double-Edged Sword in the Interplay of Infection and Autoimmunity with a Focus on Xenobiotic-Induced Immunomodulation |
| title_fullStr | The Role of T Helper (TH)17 Cells as a Double-Edged Sword in the Interplay of Infection and Autoimmunity with a Focus on Xenobiotic-Induced Immunomodulation |
| title_full_unstemmed | The Role of T Helper (TH)17 Cells as a Double-Edged Sword in the Interplay of Infection and Autoimmunity with a Focus on Xenobiotic-Induced Immunomodulation |
| title_short | The Role of T Helper (TH)17 Cells as a Double-Edged Sword in the Interplay of Infection and Autoimmunity with a Focus on Xenobiotic-Induced Immunomodulation |
| title_sort | role of t helper th 17 cells as a double edged sword in the interplay of infection and autoimmunity with a focus on xenobiotic induced immunomodulation |
| url | http://dx.doi.org/10.1155/2013/374769 |
| work_keys_str_mv | AT nasryahemdan theroleofthelperth17cellsasadoubleedgedswordintheinterplayofinfectionandautoimmunitywithafocusonxenobioticinducedimmunomodulation AT ahmedmabuelsaad theroleofthelperth17cellsasadoubleedgedswordintheinterplayofinfectionandautoimmunitywithafocusonxenobioticinducedimmunomodulation AT ulrichsack theroleofthelperth17cellsasadoubleedgedswordintheinterplayofinfectionandautoimmunitywithafocusonxenobioticinducedimmunomodulation AT nasryahemdan roleofthelperth17cellsasadoubleedgedswordintheinterplayofinfectionandautoimmunitywithafocusonxenobioticinducedimmunomodulation AT ahmedmabuelsaad roleofthelperth17cellsasadoubleedgedswordintheinterplayofinfectionandautoimmunitywithafocusonxenobioticinducedimmunomodulation AT ulrichsack roleofthelperth17cellsasadoubleedgedswordintheinterplayofinfectionandautoimmunitywithafocusonxenobioticinducedimmunomodulation |