The Consequences of Chorioamnionitis: Preterm Birth and Effects on Development
Preterm birth is a major cause of perinatal mortality and long-term morbidity. Chorioamnionitis is a common cause of preterm birth. Clinical chorioamnionitis, characterised by maternal fever, leukocytosis, tachycardia, uterine tenderness, and preterm rupture of membranes, is less common than subclin...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Pregnancy |
| Online Access: | http://dx.doi.org/10.1155/2013/412831 |
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| author | Robert Galinsky Graeme R. Polglase Stuart B. Hooper M. Jane Black Timothy J. M. Moss |
| author_facet | Robert Galinsky Graeme R. Polglase Stuart B. Hooper M. Jane Black Timothy J. M. Moss |
| author_sort | Robert Galinsky |
| collection | DOAJ |
| description | Preterm birth is a major cause of perinatal mortality and long-term morbidity. Chorioamnionitis is a common cause of preterm birth. Clinical chorioamnionitis, characterised by maternal fever, leukocytosis, tachycardia, uterine tenderness, and preterm rupture of membranes, is less common than subclinical/histologic chorioamnionitis, which is asymptomatic and defined by inflammation of the chorion, amnion, and placenta. Chorioamnionitis is often associated with a fetal inflammatory response. The fetal inflammatory response syndrome (FIRS) is defined by increased systemic inflammatory cytokine concentrations, funisitis, and fetal vasculitis. Clinical and epidemiological studies have demonstrated that FIRS leads to poor cardiorespiratory, neurological, and renal outcomes. These observations are further supported by experimental studies that have improved our understanding of the mechanisms responsible for these outcomes. This paper outlines clinical and experimental studies that have improved our current understanding of the mechanisms responsible for chorioamnionitis-induced preterm birth and explores the cellular and physiological mechanisms underlying poor cardiorespiratory, neural, retinal, and renal outcomes observed in preterm infants exposed to chorioamnionitis. |
| format | Article |
| id | doaj-art-2b331d22c3e04f84aa5b6b1ae2f4b54f |
| institution | Kabale University |
| issn | 2090-2727 2090-2735 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
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| series | Journal of Pregnancy |
| spelling | doaj-art-2b331d22c3e04f84aa5b6b1ae2f4b54f2025-02-03T01:31:56ZengWileyJournal of Pregnancy2090-27272090-27352013-01-01201310.1155/2013/412831412831The Consequences of Chorioamnionitis: Preterm Birth and Effects on DevelopmentRobert Galinsky0Graeme R. Polglase1Stuart B. Hooper2M. Jane Black3Timothy J. M. Moss4The Ritchie Centre, Monash Institute of Medical Research, Monash University, P.O. Box 5418, Clayton, VIC 3168, AustraliaThe Ritchie Centre, Monash Institute of Medical Research, Monash University, P.O. Box 5418, Clayton, VIC 3168, AustraliaThe Ritchie Centre, Monash Institute of Medical Research, Monash University, P.O. Box 5418, Clayton, VIC 3168, AustraliaDepartment of Anatomy and Developmental Biology, Monash University, Clayton, VIC 3800, AustraliaThe Ritchie Centre, Monash Institute of Medical Research, Monash University, P.O. Box 5418, Clayton, VIC 3168, AustraliaPreterm birth is a major cause of perinatal mortality and long-term morbidity. Chorioamnionitis is a common cause of preterm birth. Clinical chorioamnionitis, characterised by maternal fever, leukocytosis, tachycardia, uterine tenderness, and preterm rupture of membranes, is less common than subclinical/histologic chorioamnionitis, which is asymptomatic and defined by inflammation of the chorion, amnion, and placenta. Chorioamnionitis is often associated with a fetal inflammatory response. The fetal inflammatory response syndrome (FIRS) is defined by increased systemic inflammatory cytokine concentrations, funisitis, and fetal vasculitis. Clinical and epidemiological studies have demonstrated that FIRS leads to poor cardiorespiratory, neurological, and renal outcomes. These observations are further supported by experimental studies that have improved our understanding of the mechanisms responsible for these outcomes. This paper outlines clinical and experimental studies that have improved our current understanding of the mechanisms responsible for chorioamnionitis-induced preterm birth and explores the cellular and physiological mechanisms underlying poor cardiorespiratory, neural, retinal, and renal outcomes observed in preterm infants exposed to chorioamnionitis.http://dx.doi.org/10.1155/2013/412831 |
| spellingShingle | Robert Galinsky Graeme R. Polglase Stuart B. Hooper M. Jane Black Timothy J. M. Moss The Consequences of Chorioamnionitis: Preterm Birth and Effects on Development Journal of Pregnancy |
| title | The Consequences of Chorioamnionitis: Preterm Birth and Effects on Development |
| title_full | The Consequences of Chorioamnionitis: Preterm Birth and Effects on Development |
| title_fullStr | The Consequences of Chorioamnionitis: Preterm Birth and Effects on Development |
| title_full_unstemmed | The Consequences of Chorioamnionitis: Preterm Birth and Effects on Development |
| title_short | The Consequences of Chorioamnionitis: Preterm Birth and Effects on Development |
| title_sort | consequences of chorioamnionitis preterm birth and effects on development |
| url | http://dx.doi.org/10.1155/2013/412831 |
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