Effects of Traumeel (Tr14) on Exercise-Induced Muscle Damage Response in Healthy Subjects: A Double-Blind RCT
The present double-blind, randomized, placebo-controlled clinical trial intended to test whether ingestion of a natural combination medicine (Tr14 tablets) affects serum muscle damage and inflammatory immune response after downhill running. 96 male subjects received Tr14 tablets, which consist of 14...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/1693918 |
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| author | Kerstin Muders Christian Pilat Vanessa Deuster Torsten Frech Karsten Krüger Jörn Pons-Kühnemann Frank-Christoph Mooren |
| author_facet | Kerstin Muders Christian Pilat Vanessa Deuster Torsten Frech Karsten Krüger Jörn Pons-Kühnemann Frank-Christoph Mooren |
| author_sort | Kerstin Muders |
| collection | DOAJ |
| description | The present double-blind, randomized, placebo-controlled clinical trial intended to test whether ingestion of a natural combination medicine (Tr14 tablets) affects serum muscle damage and inflammatory immune response after downhill running. 96 male subjects received Tr14 tablets, which consist of 14 diluted biological and mineral components, or a placebo for 72 h after the exercise test, respectively. Changes in postexercise levels of various serum muscle damage and immunological markers were investigated. The area under the curve with respect to the increase (AUCi) of perceived pain score and creatine kinase (CK) were defined as primary outcome measures. While for CK the p value of the difference between the two groups is borderline, the pain score and muscle strength were not statistically significant. However, a trend towards lower levels of muscle damage (CK, p=0.05; LDH, p=0.06) in the Tr14 group was shown. Less pronounced lymphopenia (p=0.02), a trend towards a lower expression of CD69 count (p=0.07), and antigen-stimulated ICAM-1 (p=0.01) were found in the verum group. The Tr14 group showed a tendentially lower increase of neutrophils (p=0.10), BDNF (p=0.03), stem cell factor (p=0.09), and GM-CSF (p=0.09) to higher levels. The results of the current study indicate that Tr14 seems to limit exercise-induced muscle damage most likely via attenuation of both innate and adaptive immune responses. This study was registered with ClinicalTrials.gov (NCT01912469). |
| format | Article |
| id | doaj-art-2b3088ab571a4cd4a61a440a6f03b6d0 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-2b3088ab571a4cd4a61a440a6f03b6d02025-02-03T01:32:15ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/16939181693918Effects of Traumeel (Tr14) on Exercise-Induced Muscle Damage Response in Healthy Subjects: A Double-Blind RCTKerstin Muders0Christian Pilat1Vanessa Deuster2Torsten Frech3Karsten Krüger4Jörn Pons-Kühnemann5Frank-Christoph Mooren6Department of Sports Medicine, Justus Liebig University, Kugelberg 62, 35394 Giessen, GermanyDepartment of Sports Medicine, Justus Liebig University, Kugelberg 62, 35394 Giessen, GermanyDepartment of Sports Medicine, Justus Liebig University, Kugelberg 62, 35394 Giessen, GermanyDepartment of Sports Medicine, Justus Liebig University, Kugelberg 62, 35394 Giessen, GermanyDepartment of Sports Medicine, Justus Liebig University, Kugelberg 62, 35394 Giessen, GermanyMedical Statistics, Justus Liebig University, Heinrich-Buff-Ring 44, 35392 Giessen, GermanyDepartment of Sports Medicine, Justus Liebig University, Kugelberg 62, 35394 Giessen, GermanyThe present double-blind, randomized, placebo-controlled clinical trial intended to test whether ingestion of a natural combination medicine (Tr14 tablets) affects serum muscle damage and inflammatory immune response after downhill running. 96 male subjects received Tr14 tablets, which consist of 14 diluted biological and mineral components, or a placebo for 72 h after the exercise test, respectively. Changes in postexercise levels of various serum muscle damage and immunological markers were investigated. The area under the curve with respect to the increase (AUCi) of perceived pain score and creatine kinase (CK) were defined as primary outcome measures. While for CK the p value of the difference between the two groups is borderline, the pain score and muscle strength were not statistically significant. However, a trend towards lower levels of muscle damage (CK, p=0.05; LDH, p=0.06) in the Tr14 group was shown. Less pronounced lymphopenia (p=0.02), a trend towards a lower expression of CD69 count (p=0.07), and antigen-stimulated ICAM-1 (p=0.01) were found in the verum group. The Tr14 group showed a tendentially lower increase of neutrophils (p=0.10), BDNF (p=0.03), stem cell factor (p=0.09), and GM-CSF (p=0.09) to higher levels. The results of the current study indicate that Tr14 seems to limit exercise-induced muscle damage most likely via attenuation of both innate and adaptive immune responses. This study was registered with ClinicalTrials.gov (NCT01912469).http://dx.doi.org/10.1155/2016/1693918 |
| spellingShingle | Kerstin Muders Christian Pilat Vanessa Deuster Torsten Frech Karsten Krüger Jörn Pons-Kühnemann Frank-Christoph Mooren Effects of Traumeel (Tr14) on Exercise-Induced Muscle Damage Response in Healthy Subjects: A Double-Blind RCT Mediators of Inflammation |
| title | Effects of Traumeel (Tr14) on Exercise-Induced Muscle Damage Response in Healthy Subjects: A Double-Blind RCT |
| title_full | Effects of Traumeel (Tr14) on Exercise-Induced Muscle Damage Response in Healthy Subjects: A Double-Blind RCT |
| title_fullStr | Effects of Traumeel (Tr14) on Exercise-Induced Muscle Damage Response in Healthy Subjects: A Double-Blind RCT |
| title_full_unstemmed | Effects of Traumeel (Tr14) on Exercise-Induced Muscle Damage Response in Healthy Subjects: A Double-Blind RCT |
| title_short | Effects of Traumeel (Tr14) on Exercise-Induced Muscle Damage Response in Healthy Subjects: A Double-Blind RCT |
| title_sort | effects of traumeel tr14 on exercise induced muscle damage response in healthy subjects a double blind rct |
| url | http://dx.doi.org/10.1155/2016/1693918 |
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