GnIH secreted by green light exposure, regulates bone mass through the activation of Gpr147
Abstract Reproductive hormones associated with the hypothalamic-pituitary-gonadal (HPG) axis are closely linked to bone homeostasis. In this study, we demonstrate that Gonadotropin inhibitory hormone (GnIH, one of the key reproductive hormones upstream of the HPG axis) plays an indispensable role in...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-01-01
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| Series: | Bone Research |
| Online Access: | https://doi.org/10.1038/s41413-024-00389-7 |
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| author | Yu You Konglin Huo Liang He Tongyue Wang Lei Zhao Rong Li Xiaoqing Cheng Xuebin Ma Zhiying Yue Stefan Siwko Ning Wang Lujian Liao Mingyao Liu Jian Luo |
| author_facet | Yu You Konglin Huo Liang He Tongyue Wang Lei Zhao Rong Li Xiaoqing Cheng Xuebin Ma Zhiying Yue Stefan Siwko Ning Wang Lujian Liao Mingyao Liu Jian Luo |
| author_sort | Yu You |
| collection | DOAJ |
| description | Abstract Reproductive hormones associated with the hypothalamic-pituitary-gonadal (HPG) axis are closely linked to bone homeostasis. In this study, we demonstrate that Gonadotropin inhibitory hormone (GnIH, one of the key reproductive hormones upstream of the HPG axis) plays an indispensable role in regulating bone homeostasis and maintaining bone mass. We find that deficiency of GnIH or its receptor Gpr147 leads to a significant reduction in bone mineral density (BMD) in mice primarily by enhancement of osteoclast activation in vivo and in vitro. Mechanistically, GnIH/Gpr147 inhibits osteoclastogenesis by the PI3K/AKT, MAPK, NF-κB and Nfatc1 signaling pathways. Furthermore, GnIH treatment was able to alleviate bone loss in aging, ovariectomy (OVX) or LPS-induced mice. Moreover, the therapy using green light promotes the release of GnIH and rescues OVX-induced bone loss. In humans, serum GnIH increases and bone resorption markers decrease after green light exposure. Therefore, our study elucidates that GnIH plays an important role in maintaining bone homeostasis via modulating osteoclast differentiation and demonstrates the potential of GnIH therapy or green light therapy in preventing osteoporosis. |
| format | Article |
| id | doaj-art-2b1dcd745dfc4a2f8e059004a56a5291 |
| institution | Kabale University |
| issn | 2095-6231 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Bone Research |
| spelling | doaj-art-2b1dcd745dfc4a2f8e059004a56a52912025-01-26T12:19:51ZengNature Publishing GroupBone Research2095-62312025-01-0113111210.1038/s41413-024-00389-7GnIH secreted by green light exposure, regulates bone mass through the activation of Gpr147Yu You0Konglin Huo1Liang He2Tongyue Wang3Lei Zhao4Rong Li5Xiaoqing Cheng6Xuebin Ma7Zhiying Yue8Stefan Siwko9Ning Wang10Lujian Liao11Mingyao Liu12Jian Luo13Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal UniversityShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal UniversityYangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Tongji University School of MedicineYangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Tongji University School of MedicineYangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Tongji University School of MedicineYangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Tongji University School of MedicineShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal UniversityShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal UniversityPrecision Research Center for Refractory Diseases, Shanghai General Hospital,Shanghai Jiaotong University, School of MedicineDepartment of Translational Medical Sciences, Institute of Biosciences and Technology, Texas A&M University Health Science CenterLeicester Cancer Research Centre, Department of Genetics and Genome Biology, University of LeicesterShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal UniversityShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal UniversityYangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Tongji University School of MedicineAbstract Reproductive hormones associated with the hypothalamic-pituitary-gonadal (HPG) axis are closely linked to bone homeostasis. In this study, we demonstrate that Gonadotropin inhibitory hormone (GnIH, one of the key reproductive hormones upstream of the HPG axis) plays an indispensable role in regulating bone homeostasis and maintaining bone mass. We find that deficiency of GnIH or its receptor Gpr147 leads to a significant reduction in bone mineral density (BMD) in mice primarily by enhancement of osteoclast activation in vivo and in vitro. Mechanistically, GnIH/Gpr147 inhibits osteoclastogenesis by the PI3K/AKT, MAPK, NF-κB and Nfatc1 signaling pathways. Furthermore, GnIH treatment was able to alleviate bone loss in aging, ovariectomy (OVX) or LPS-induced mice. Moreover, the therapy using green light promotes the release of GnIH and rescues OVX-induced bone loss. In humans, serum GnIH increases and bone resorption markers decrease after green light exposure. Therefore, our study elucidates that GnIH plays an important role in maintaining bone homeostasis via modulating osteoclast differentiation and demonstrates the potential of GnIH therapy or green light therapy in preventing osteoporosis.https://doi.org/10.1038/s41413-024-00389-7 |
| spellingShingle | Yu You Konglin Huo Liang He Tongyue Wang Lei Zhao Rong Li Xiaoqing Cheng Xuebin Ma Zhiying Yue Stefan Siwko Ning Wang Lujian Liao Mingyao Liu Jian Luo GnIH secreted by green light exposure, regulates bone mass through the activation of Gpr147 Bone Research |
| title | GnIH secreted by green light exposure, regulates bone mass through the activation of Gpr147 |
| title_full | GnIH secreted by green light exposure, regulates bone mass through the activation of Gpr147 |
| title_fullStr | GnIH secreted by green light exposure, regulates bone mass through the activation of Gpr147 |
| title_full_unstemmed | GnIH secreted by green light exposure, regulates bone mass through the activation of Gpr147 |
| title_short | GnIH secreted by green light exposure, regulates bone mass through the activation of Gpr147 |
| title_sort | gnih secreted by green light exposure regulates bone mass through the activation of gpr147 |
| url | https://doi.org/10.1038/s41413-024-00389-7 |
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