Optimal control of a Tuberculosis model with state and control delays
We introduce delays in a tuberculosis (TB) model, representing the time delay on the diagnosis and commencement of treatment of individuals with active TB infection. The stability of the disease free and endemic equilibriums is investigated for any time delay. Corresponding optimal control problems,...
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| Language: | English |
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AIMS Press
2016-12-01
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| Series: | Mathematical Biosciences and Engineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2017021 |
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| author | Cristiana J. Silva Helmut Maurer Delfim F. M. Torres |
| author_facet | Cristiana J. Silva Helmut Maurer Delfim F. M. Torres |
| author_sort | Cristiana J. Silva |
| collection | DOAJ |
| description | We introduce delays in a tuberculosis (TB) model, representing the time delay on the diagnosis and commencement of treatment of individuals with active TB infection. The stability of the disease free and endemic equilibriums is investigated for any time delay. Corresponding optimal control problems, with time delays in both state and control variables, are formulated and studied. Although it is well-known that there is a delay between two to eight weeks between TB infection and reaction of body's immune system to tuberculin, delays for the active infected to be detected and treated, and delays on the treatment of persistent latent individuals due to clinical and patient reasons, which clearly justifies the introduction of time delays on state and control measures, our work seems to be the first to consider such time-delays for TB and apply time-delay optimal control to carry out the optimality analysis. |
| format | Article |
| id | doaj-art-2b0e9911a13944c786b39c2c103c8195 |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2016-12-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-2b0e9911a13944c786b39c2c103c81952025-01-24T02:39:32ZengAIMS PressMathematical Biosciences and Engineering1551-00182016-12-0114132133710.3934/mbe.2017021Optimal control of a Tuberculosis model with state and control delaysCristiana J. Silva0Helmut Maurer1Delfim F. M. Torres2Center for Research and Development in Mathematics and Applications (CIDMA), Department of Mathematics, University of Aveiro, 3810-193 Aveiro, PortugalInstitute of Computational and Applied Mathematics, University of Münster, D-48149 Münster, GermanyCenter for Research and Development in Mathematics and Applications (CIDMA), Department of Mathematics, University of Aveiro, 3810-193 Aveiro, PortugalWe introduce delays in a tuberculosis (TB) model, representing the time delay on the diagnosis and commencement of treatment of individuals with active TB infection. The stability of the disease free and endemic equilibriums is investigated for any time delay. Corresponding optimal control problems, with time delays in both state and control variables, are formulated and studied. Although it is well-known that there is a delay between two to eight weeks between TB infection and reaction of body's immune system to tuberculin, delays for the active infected to be detected and treated, and delays on the treatment of persistent latent individuals due to clinical and patient reasons, which clearly justifies the introduction of time delays on state and control measures, our work seems to be the first to consider such time-delays for TB and apply time-delay optimal control to carry out the optimality analysis.https://www.aimspress.com/article/doi/10.3934/mbe.2017021tuberculosistime delaysstabilityoptimal control |
| spellingShingle | Cristiana J. Silva Helmut Maurer Delfim F. M. Torres Optimal control of a Tuberculosis model with state and control delays Mathematical Biosciences and Engineering tuberculosis time delays stability optimal control |
| title | Optimal control of a Tuberculosis model with state and control delays |
| title_full | Optimal control of a Tuberculosis model with state and control delays |
| title_fullStr | Optimal control of a Tuberculosis model with state and control delays |
| title_full_unstemmed | Optimal control of a Tuberculosis model with state and control delays |
| title_short | Optimal control of a Tuberculosis model with state and control delays |
| title_sort | optimal control of a tuberculosis model with state and control delays |
| topic | tuberculosis time delays stability optimal control |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2017021 |
| work_keys_str_mv | AT cristianajsilva optimalcontrolofatuberculosismodelwithstateandcontroldelays AT helmutmaurer optimalcontrolofatuberculosismodelwithstateandcontroldelays AT delfimfmtorres optimalcontrolofatuberculosismodelwithstateandcontroldelays |