Trehalose enhances macrophage autophagy to promote myelin debris clearance after spinal cord injury

Trehalose enhances macrophage autophagy to promote myelin debris clearance after spinal cord injury

Abstract Background Myelin-laden foamy macrophages accumulate extensively in the lesion epicenter, exhibiting characteristics of autophagolysosomal dysfunction, which leads to prolonged inflammatory responses after spinal cord injury (SCI). Trehalose, known for its neuroprotective properties as an a...

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Main Authors: Zhida Ma, Congpeng Meng, Xiang Wang, Yuanzhe Zhao, Jingwen Wang, Yihao Chen, Yiteng Li, Yan Jiang, Fangru Ouyang, Jianjian Li, Meige Zheng, Li Cheng, Juehua Jing
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cell & Bioscience
Subjects:
Trehalose
Spinal cord injury
Foamy macrophages
Autophagy
Myelin debris
Online Access:https://doi.org/10.1186/s13578-025-01357-2
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https://doi.org/10.1186/s13578-025-01357-2

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