Sigma‐1 receptor attenuates osteoclastogenesis by promoting ER‐associated degradation of SERCA2

Sigma‐1 receptor attenuates osteoclastogenesis by promoting ER‐associated degradation of SERCA2

Abstract Sigma‐1 receptor (Sigmar1) is a specific chaperone located in the mitochondria‐associated endoplasmic reticulum membrane (MAM) and plays a role in several physiological processes. However, the role of Sigmar1 in bone homeostasis remains unknown. Here, we show that mice lacking Sigmar1 exhib...

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Main Authors: Xiaoan Wei, Zeyu Zheng, Zhenhua Feng, Lin Zheng, Siyue Tao, Bingjie Zheng, Bao Huang, Xuyang Zhang, Junhui Liu, Yilei Chen, Wentian Zong, Zhi Shan, Shunwu Fan, Jian Chen, Fengdong Zhao
Format: Article
Language:English
Published: Springer Nature 2022-05-01
Series:EMBO Molecular Medicine
Subjects:
ER‐associated degradation
dimemorfan
osteoporosis
SERCA2
Sigma‐1 receptor
Online Access:https://doi.org/10.15252/emmm.202115373
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https://doi.org/10.15252/emmm.202115373

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