The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanisms
Serum urate (SU) levels are significantly elevated in conditions such as gout, type 2 diabetes (T2D), obesity, and other metabolic syndromes. Recently, due to the high prevalence of hyperuricemia (HUA), numerous clinical connections between SU and musculoskeletal disorders like sarcopenia, osteoarth...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1515176/full |
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| author | Jing Zhang Na Sun Wanhao Zhang Wenjie Yue Xiaochen Qu Xiaochen Qu Zhonghai Li Zhonghai Li Gang Xu Gang Xu |
| author_facet | Jing Zhang Na Sun Wanhao Zhang Wenjie Yue Xiaochen Qu Xiaochen Qu Zhonghai Li Zhonghai Li Gang Xu Gang Xu |
| author_sort | Jing Zhang |
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| description | Serum urate (SU) levels are significantly elevated in conditions such as gout, type 2 diabetes (T2D), obesity, and other metabolic syndromes. Recently, due to the high prevalence of hyperuricemia (HUA), numerous clinical connections between SU and musculoskeletal disorders like sarcopenia, osteoarthritis (OA), rheumatoid arthritis (RA), intervertebral disc degeneration (IDD), and osteoporosis (OP) have been identified. This review discusses the mechanisms linking SU to musculoskeletal disorders, as well as the clinical associations of SU with conditions such as sarcopenia, T2D with sarcopenia, McArdle disease, heart failure, gout, OA, IDD, OP and exercise-induced acute kidney injury (EIAKI), offering valuable insights for improved prevention and treatment strategies. Mechanisms linking SU to musculoskeletal disorders include oxidative stress, MSU (monosodium urate) crystal deposition, inflammation, and other factors. In adults, both age and SU levels should be considered for preventing sarcopenia, while gender and SU may directly impact muscle mass in children and adolescents. HUA and gout may be risk factors for OA progression, although some reports suggest otherwise. A U-shaped relationship between SU and IDD has been reported, particularly in Chinese men, indicating lower or higher SU level may be risk factors for IDD. Maintaining SU levels within a certain range may help prevent OP and fractures. Future research, including epidemiological studies and new pathogenesis findings, will further clarify the relationship between musculoskeletal diseases and SU. |
| format | Article |
| id | doaj-art-2b062ce5d50f4ae190131b340559073b |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-2b062ce5d50f4ae190131b340559073b2025-02-04T05:28:16ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-02-011610.3389/fendo.2025.15151761515176The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanismsJing Zhang0Na Sun1Wanhao Zhang2Wenjie Yue3Xiaochen Qu4Xiaochen Qu5Zhonghai Li6Zhonghai Li7Gang Xu8Gang Xu9Department of Orthopaedics, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Pharmacy, The Third People’s Hospital of Dalian, Dalian, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaKey Laboratory of Molecular Mechanism for Repair and Remodeling of Orthopaedic Diseases, Dalian, Liaoning, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaKey Laboratory of Molecular Mechanism for Repair and Remodeling of Orthopaedic Diseases, Dalian, Liaoning, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaKey Laboratory of Molecular Mechanism for Repair and Remodeling of Orthopaedic Diseases, Dalian, Liaoning, ChinaSerum urate (SU) levels are significantly elevated in conditions such as gout, type 2 diabetes (T2D), obesity, and other metabolic syndromes. Recently, due to the high prevalence of hyperuricemia (HUA), numerous clinical connections between SU and musculoskeletal disorders like sarcopenia, osteoarthritis (OA), rheumatoid arthritis (RA), intervertebral disc degeneration (IDD), and osteoporosis (OP) have been identified. This review discusses the mechanisms linking SU to musculoskeletal disorders, as well as the clinical associations of SU with conditions such as sarcopenia, T2D with sarcopenia, McArdle disease, heart failure, gout, OA, IDD, OP and exercise-induced acute kidney injury (EIAKI), offering valuable insights for improved prevention and treatment strategies. Mechanisms linking SU to musculoskeletal disorders include oxidative stress, MSU (monosodium urate) crystal deposition, inflammation, and other factors. In adults, both age and SU levels should be considered for preventing sarcopenia, while gender and SU may directly impact muscle mass in children and adolescents. HUA and gout may be risk factors for OA progression, although some reports suggest otherwise. A U-shaped relationship between SU and IDD has been reported, particularly in Chinese men, indicating lower or higher SU level may be risk factors for IDD. Maintaining SU levels within a certain range may help prevent OP and fractures. Future research, including epidemiological studies and new pathogenesis findings, will further clarify the relationship between musculoskeletal diseases and SU.https://www.frontiersin.org/articles/10.3389/fendo.2025.1515176/fulluric acidmusculoskeletal diseasessarcopeniaosteoarthritisintervertebral disc degenerationgout |
| spellingShingle | Jing Zhang Na Sun Wanhao Zhang Wenjie Yue Xiaochen Qu Xiaochen Qu Zhonghai Li Zhonghai Li Gang Xu Gang Xu The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanisms Frontiers in Endocrinology uric acid musculoskeletal diseases sarcopenia osteoarthritis intervertebral disc degeneration gout |
| title | The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanisms |
| title_full | The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanisms |
| title_fullStr | The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanisms |
| title_full_unstemmed | The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanisms |
| title_short | The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanisms |
| title_sort | impact of uric acid on musculoskeletal diseases clinical associations and underlying mechanisms |
| topic | uric acid musculoskeletal diseases sarcopenia osteoarthritis intervertebral disc degeneration gout |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1515176/full |
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