Solidified reverse micellar solution-based chitosan-coated solid lipid nanoparticles as a new approach to enhance oral delivery of artemether in malaria treatment

Solidified reverse micellar solution-based chitosan-coated solid lipid nanoparticles as a new approach to enhance oral delivery of artemether in malaria treatment

Abstract Solidified reverse micellar technology and surface-modification are promising techniques for improving the biopharmaceutical properties of poorly water-soluble drugs such as artemether, a first-line antimalarial drug. Thus, the aim of this study was to develop and evaluate artemether-loaded...

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Main Authors: Franklin Chimaobi Kenechukwu, Kingsley Chinazam Ugwu, Chibuzor Stanley Offorbuike, Enyi Moses Ojukwu, Thaddeus Harrison Gugu, Reuben Ejike Eze, Chinazom Precious Agbo, Mumuni Audu Momoh, Anthony Ikechukwu Onah, Chinekwu Sherridan Nwagwu, Onyinyechi Lydia Ugorji, Emmanuel Chekwube Ossai, Calister Elochukwu Ugwu, Paul Achile Akpa, Adaeze Chidiebere Echezona, Samuel WisdomofGod Uzondu, Chimaobi Odinaka Ugorji, Wilfred Ikechukwu Ugwuoke, Teerapol Srichana, Anthony Amaechi Attama
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BMC Chemistry
Subjects:
Solidified reverse micellar solution
Antimalarial activity
Chitosan
Solid lipid nanoparticles
Artemether
Plasmodium berghei
Online Access:https://doi.org/10.1186/s13065-025-01422-4
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