Oxygen vacancy-engineered bimetallic nanozymes for disrupting electron transport chain and synergistic multi-enzyme activity to reverse oxaliplatin resistance in colorectal cancer

Oxygen vacancy-engineered bimetallic nanozymes for disrupting electron transport chain and synergistic multi-enzyme activity to reverse oxaliplatin resistance in colorectal cancer

Abstract In colorectal cancer treatment, chemotherapeutic agents induce reactive oxygen species (ROS) production, which promotes NAD+ accumulation in tumor cells, reducing treatment sensitivity and worsening patient prognosis. Targeted depletion of NAD+ presents a promising strategy to overcome tumo...

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Bibliographic Details
Main Authors: Dong Zhong, Xiaoxin Yang, Jinhui Yang, Zhisheng Luo, Zhichao Feng, Mengtian Ma, Yunjie Liao, Yongxiang Tang, Yu Wen, Jun Liu, Shuo Hu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Nanobiotechnology
Subjects:
ETC disruption
Bimetallic nanozymes
NAD+ depletion
Multi-enzyme activity
Oxaliplatin resistance
Online Access:https://doi.org/10.1186/s12951-025-03417-8
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