The effect of Rsk2 on TNFα-mediated bone loss in the TMJ and craniofacial skeleton

The effect of Rsk2 on TNFα-mediated bone loss in the TMJ and craniofacial skeleton

Abstract Objectives This study aims to investigate the impact of the pro-osteoblastogenic ERK-activated ribosomal S6 kinase (Rsk2) on Tumor necrosis factor (TNF)α-induced bone loss in the craniofacial system, focusing on its role in rheumatoid arthritis (RA). The objective is to understand whether R...

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Main Authors: Gina Marie Georgi, Frédéric Bachmann, Julia Luther, Anja Derer, Patrick Heimel, Stefan Tangl, Bärbel Kahl-Nieke, Aaron LeBlanc, Jill Helms, Georg Schett, Christian Hirsch, Reinhard Gruber, Michael Amling, Thorsten Schinke, Till Koehne, Julian Petersen
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BMC Oral Health
Subjects:
Geometric morphometrics
Inflammation
Rheumatoid arthritis
Transgenic mouse
Temporomandibular joints
Tumor necrosis factor-α, ribosomal s6 kinase 2
Online Access:https://doi.org/10.1186/s12903-025-05779-9
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