Estrogen-related receptor gamma is a regulator of mitochondrial, autophagy, and immediate-early gene programs in spiny projection neurons: Relevance for transcriptional changes in Huntington disease

Estrogen-related receptor gamma is a regulator of mitochondrial, autophagy, and immediate-early gene programs in spiny projection neurons: Relevance for transcriptional changes in Huntington disease

Mitochondrial dysfunction, transcriptional dysregulation, and protein aggregation are hallmarks of multiple neurodegenerative disorders, including Huntington's disease (HD). Strategies are needed to counteract these processes to restore neuronal health and function in HD. Recent evidence indica...

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Bibliographic Details
Main Authors: Stephanie N. Fox, Cody H. Savage, Narcy R. Amireddy, Laura J. McMeekin, David K. Crossman, Peter J. Detloff, Michelle Gray, Rita M. Cowell
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Neurobiology of Disease
Subjects:
Transcription factor
Estrogen-related receptor gamma
Huntington's disease
Activity-dependent genes
Spiny projection neurons
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125000348
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