Unlocking Dabrafenib’s Potential: A Quality by Design (QBD) Journey to Enhance Permeation and Oral Bioavailability through Nanosponge Formulation

Unlocking Dabrafenib’s Potential: A Quality by Design (QBD) Journey to Enhance Permeation and Oral Bioavailability through Nanosponge Formulation

Abstract This research aims to create dabrafenib (DBF)-loaded nanosponges (NSPs) using β-cyclodextrin (β-CD) and diphenyl carbonate (DPC) as linker to improve oral bioavailability. DBF-loaded β-CD NSPs were synthesized by finely adjusting the molar ratio of β-CD to DPC and optimizing the stirring ra...

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Bibliographic Details
Main Authors:	Konda Sri Chaya Reddy, Darna Bhikshapathi, Jaini Pavan Kumar
Format:	Article
Language:	English
Published:	Universidade de São Paulo 2025-01-01
Series:	Brazilian Journal of Pharmaceutical Sciences
Subjects:	Box-Behnken design Cross-linker Cyclodextrin Solubility Dabrafenib Diphenyl carbonate Quality by Design
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502025000100322&lng=en&tlng=en
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