Mutations in NEK1 cause ciliary dysfunction as a novel pathogenic mechanism in amyotrophic lateral sclerosis

Mutations in NEK1 cause ciliary dysfunction as a novel pathogenic mechanism in amyotrophic lateral sclerosis

Abstract Background Neuronal primary cilia, vital for signaling and cell-cycle regulation, have been implicated in maintaining neuronal identity. While a link between primary ciliary defects and neurodegenerative diseases is emerging, the precise pathological mechanisms remain unclear. Methods We st...

Full description

Saved in:
Bibliographic Details
Main Authors: Min-Young Noh, Seong-il Oh, Young-Eun Kim, Sun Joo Cha, Wonjae Sung, Ki-Wook Oh, Yurim Park, Ji Young Mun, Chang-Seok Ki, Minyeop Nahm, Seung Hyun Kim
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Molecular Neurodegeneration
Subjects:
Amyotrophic lateral sclerosis
NEK1
Primary cilia
Cell cycle
Microtubule
Mitochondria
Online Access:https://doi.org/10.1186/s13024-025-00848-7
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items