Essential Oils May Lead α-Synuclein towards Toxic Fibrils Formation
α-Synuclein (α-Syn) fibrillation links with Parkinson’s disease (PD) and several related syndromes. It is believed that exposure to the factors which promote fibrillation may induce and progress such neurodegenerative diseases (NDs). Herein, the effects of some wildly used essential oils including M...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2016/6219249 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551724584271872 |
|---|---|
| author | Dina Morshedi Mahour Nasouti |
| author_facet | Dina Morshedi Mahour Nasouti |
| author_sort | Dina Morshedi |
| collection | DOAJ |
| description | α-Synuclein (α-Syn) fibrillation links with Parkinson’s disease (PD) and several related syndromes. It is believed that exposure to the factors which promote fibrillation may induce and progress such neurodegenerative diseases (NDs). Herein, the effects of some wildly used essential oils including Myrtus communis (M. communis) on α-Syn fibrillation were examined. M. communis particularly increased α-Syn fibrillation in a concentration dependent manner. Given that applications of M. communis are very extensive in Asian societies, especially Zoroastrians, this study was extended towards its role on α-Syn fibrillation/cytotoxicity. By using a unilamellar vesicle, it was shown that the aggregated species with tendency to perturb membrane were increased in the presence of M. communis. In this regard, the cytotoxicity of α-Syn on SH-SH5Y cells was also increased significantly. Inappropriately, the effects of fibrillation inhibitors, baicalein and cuminaldehyde, were modulated in the presence of M. communis. However, major components of M. communis did not induce fibrillation and also the effect of M. communis was limited on other fibrinogenic proteins. Assuming that essential oils have the ability to pass through the blood brain barrier (BBB) along with the popular attention on aromatherapy for the incurable ND, these findings suggest an implementation of fibrillation tests for essential oils. |
| format | Article |
| id | doaj-art-2ab4e490dfa8457e91e6d8bf5af7217d |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-2ab4e490dfa8457e91e6d8bf5af7217d2025-02-03T06:00:40ZengWileyParkinson's Disease2090-80832042-00802016-01-01201610.1155/2016/62192496219249Essential Oils May Lead α-Synuclein towards Toxic Fibrils FormationDina Morshedi0Mahour Nasouti1National Institute of Genetic Engineering and Biotechnology, Department of Industrial & Environmental Biotechnology, Shahrak-e Pajoohesh, km 15, Tehran-Karaj Highway, P.O. Box 14965/161, Tehran, IranNational Institute of Genetic Engineering and Biotechnology, Department of Industrial & Environmental Biotechnology, Shahrak-e Pajoohesh, km 15, Tehran-Karaj Highway, P.O. Box 14965/161, Tehran, Iranα-Synuclein (α-Syn) fibrillation links with Parkinson’s disease (PD) and several related syndromes. It is believed that exposure to the factors which promote fibrillation may induce and progress such neurodegenerative diseases (NDs). Herein, the effects of some wildly used essential oils including Myrtus communis (M. communis) on α-Syn fibrillation were examined. M. communis particularly increased α-Syn fibrillation in a concentration dependent manner. Given that applications of M. communis are very extensive in Asian societies, especially Zoroastrians, this study was extended towards its role on α-Syn fibrillation/cytotoxicity. By using a unilamellar vesicle, it was shown that the aggregated species with tendency to perturb membrane were increased in the presence of M. communis. In this regard, the cytotoxicity of α-Syn on SH-SH5Y cells was also increased significantly. Inappropriately, the effects of fibrillation inhibitors, baicalein and cuminaldehyde, were modulated in the presence of M. communis. However, major components of M. communis did not induce fibrillation and also the effect of M. communis was limited on other fibrinogenic proteins. Assuming that essential oils have the ability to pass through the blood brain barrier (BBB) along with the popular attention on aromatherapy for the incurable ND, these findings suggest an implementation of fibrillation tests for essential oils.http://dx.doi.org/10.1155/2016/6219249 |
| spellingShingle | Dina Morshedi Mahour Nasouti Essential Oils May Lead α-Synuclein towards Toxic Fibrils Formation Parkinson's Disease |
| title | Essential Oils May Lead α-Synuclein towards Toxic Fibrils Formation |
| title_full | Essential Oils May Lead α-Synuclein towards Toxic Fibrils Formation |
| title_fullStr | Essential Oils May Lead α-Synuclein towards Toxic Fibrils Formation |
| title_full_unstemmed | Essential Oils May Lead α-Synuclein towards Toxic Fibrils Formation |
| title_short | Essential Oils May Lead α-Synuclein towards Toxic Fibrils Formation |
| title_sort | essential oils may lead α synuclein towards toxic fibrils formation |
| url | http://dx.doi.org/10.1155/2016/6219249 |
| work_keys_str_mv | AT dinamorshedi essentialoilsmayleadasynucleintowardstoxicfibrilsformation AT mahournasouti essentialoilsmayleadasynucleintowardstoxicfibrilsformation |