White Matter Biomarkers Associated with Motor Change in Individuals with Stroke: A Continuous Theta Burst Stimulation Study
Continuous theta burst stimulation (cTBS) is a form of noninvasive repetitive brain stimulation that, when delivered over the contralesional hemisphere, can influence the excitability of the ipsilesional hemisphere in individuals with stroke. cTBS applied prior to skilled motor practice intervention...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2019/7092496 |
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| author | K. P. Wadden S. Peters M. R. Borich J. L. Neva K. S. Hayward C. S. Mang N. J. Snow K. E. Brown T. S. Woodward S. K. Meehan L. A. Boyd |
| author_facet | K. P. Wadden S. Peters M. R. Borich J. L. Neva K. S. Hayward C. S. Mang N. J. Snow K. E. Brown T. S. Woodward S. K. Meehan L. A. Boyd |
| author_sort | K. P. Wadden |
| collection | DOAJ |
| description | Continuous theta burst stimulation (cTBS) is a form of noninvasive repetitive brain stimulation that, when delivered over the contralesional hemisphere, can influence the excitability of the ipsilesional hemisphere in individuals with stroke. cTBS applied prior to skilled motor practice interventions may augment motor learning; however, there is a high degree of variability in individual response to this intervention. The main objective of the present study was to assess white matter biomarkers of response to cTBS paired with skilled motor practice in individuals with chronic stroke. We tested the effects of stimulation of the contralesional hemisphere at the site of the primary motor cortex (M1c) or primary somatosensory cortex (S1c) and a third group who received sham stimulation. Within each stimulation group, individuals were categorized into responders or nonresponders based on their capacity for motor skill change. Baseline diffusion tensor imaging (DTI) indexed the underlying white matter microstructure of a previously known motor learning network, named the constrained motor connectome (CMC), as well as the corticospinal tract (CST) of lesioned and nonlesioned hemispheres. Across practice, there were no differential group effects. However, when categorized as responders vs. nonresponders using change in motor behaviour, we demonstrated a significant difference in CMC microstructural properties (as measured by fractional anisotropy (FA)) for individuals in M1c and S1c groups. There were no significant differences between responders and nonresponders in clinical baseline measures or microstructural properties (FA) in the CST. The present study identifies a white matter biomarker, which extends beyond the CST, advancing our understanding of the importance of white matter networks for motor after stroke. |
| format | Article |
| id | doaj-art-2ab00f1b753d4505aaff30950995cd5f |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-2ab00f1b753d4505aaff30950995cd5f2025-02-03T01:12:01ZengWileyNeural Plasticity2090-59041687-54432019-01-01201910.1155/2019/70924967092496White Matter Biomarkers Associated with Motor Change in Individuals with Stroke: A Continuous Theta Burst Stimulation StudyK. P. Wadden0S. Peters1M. R. Borich2J. L. Neva3K. S. Hayward4C. S. Mang5N. J. Snow6K. E. Brown7T. S. Woodward8S. K. Meehan9L. A. Boyd10Faculty of Medicine, Memorial University of Newfoundland, St. John’s, CanadaUniversity of British Columbia, Department of Physical Therapy, Vancouver, CanadaDivision of Physical Therapy, Department of Rehabilitation Medicine, Emory University School of Medicine, Atlanta, USAUniversity of British Columbia, Department of Physical Therapy, Vancouver, CanadaUniversity of British Columbia, Department of Physical Therapy, Vancouver, CanadaUniversity of Regina, Faculty of Kinesiology and Health Studies, Regina, CanadaFaculty of Medicine, Memorial University of Newfoundland, St. John’s, CanadaDepartment of Clinical and Movement Neurosciences, University College London, London, UKUniversity of British Columbia, Department of Psychiatry, Vancouver, BC, CanadaDepartment of Kinesiology, University of Waterloo, Waterloo, CanadaUniversity of British Columbia, Department of Physical Therapy, Vancouver, CanadaContinuous theta burst stimulation (cTBS) is a form of noninvasive repetitive brain stimulation that, when delivered over the contralesional hemisphere, can influence the excitability of the ipsilesional hemisphere in individuals with stroke. cTBS applied prior to skilled motor practice interventions may augment motor learning; however, there is a high degree of variability in individual response to this intervention. The main objective of the present study was to assess white matter biomarkers of response to cTBS paired with skilled motor practice in individuals with chronic stroke. We tested the effects of stimulation of the contralesional hemisphere at the site of the primary motor cortex (M1c) or primary somatosensory cortex (S1c) and a third group who received sham stimulation. Within each stimulation group, individuals were categorized into responders or nonresponders based on their capacity for motor skill change. Baseline diffusion tensor imaging (DTI) indexed the underlying white matter microstructure of a previously known motor learning network, named the constrained motor connectome (CMC), as well as the corticospinal tract (CST) of lesioned and nonlesioned hemispheres. Across practice, there were no differential group effects. However, when categorized as responders vs. nonresponders using change in motor behaviour, we demonstrated a significant difference in CMC microstructural properties (as measured by fractional anisotropy (FA)) for individuals in M1c and S1c groups. There were no significant differences between responders and nonresponders in clinical baseline measures or microstructural properties (FA) in the CST. The present study identifies a white matter biomarker, which extends beyond the CST, advancing our understanding of the importance of white matter networks for motor after stroke.http://dx.doi.org/10.1155/2019/7092496 |
| spellingShingle | K. P. Wadden S. Peters M. R. Borich J. L. Neva K. S. Hayward C. S. Mang N. J. Snow K. E. Brown T. S. Woodward S. K. Meehan L. A. Boyd White Matter Biomarkers Associated with Motor Change in Individuals with Stroke: A Continuous Theta Burst Stimulation Study Neural Plasticity |
| title | White Matter Biomarkers Associated with Motor Change in Individuals with Stroke: A Continuous Theta Burst Stimulation Study |
| title_full | White Matter Biomarkers Associated with Motor Change in Individuals with Stroke: A Continuous Theta Burst Stimulation Study |
| title_fullStr | White Matter Biomarkers Associated with Motor Change in Individuals with Stroke: A Continuous Theta Burst Stimulation Study |
| title_full_unstemmed | White Matter Biomarkers Associated with Motor Change in Individuals with Stroke: A Continuous Theta Burst Stimulation Study |
| title_short | White Matter Biomarkers Associated with Motor Change in Individuals with Stroke: A Continuous Theta Burst Stimulation Study |
| title_sort | white matter biomarkers associated with motor change in individuals with stroke a continuous theta burst stimulation study |
| url | http://dx.doi.org/10.1155/2019/7092496 |
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