Structural Modifications Reveal Dual Functions of the C-4 Carbonyl Group in the Fatty Acid Chain of Ipomoeassin F

Structural Modifications Reveal Dual Functions of the C-4 Carbonyl Group in the Fatty Acid Chain of Ipomoeassin F

Ipomoeassin F (Ipom-F) is a plant-derived macrocyclic resin glycoside that potently inhibits cancer cell growth through blockage of Sec61-mediated protein translocation at the endoplasmic reticulum. Recently, detailed structural information on how Ipom-F binds to Sec61α was obtained using Cryo-EM, w...

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Bibliographic Details
Main Authors: Arman Khosravi, Precious Nnamdi, Alexa May, Kelsey Slattery, Robert E. Sammelson, Wei Q. Shi
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Molecules
Subjects:
ipomoeassin F
resin glycosides
ring-opened analogues
cytotoxicity
Sec61 translocon
Online Access:https://www.mdpi.com/1420-3049/30/2/400
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